Is extereme cytoreductive surgery beneficial to survival ın malignant peritoneal mesothelioma?

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dc.contributor.authorMollaoglu, Murat Can
dc.contributor.authorKarabacak, Ufuk
dc.contributor.authorBostanci, Meric Emre
dc.contributor.authorSeven, Turan Eray
dc.contributor.authorKaradayi, Kursat
dc.date.accessioned2024-10-26T18:06:05Z
dc.date.available2024-10-26T18:06:05Z
dc.date.issued2024
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractIntroduction: Malign peritoneal mesothelioma (MPM) is an uncommon disease that is difficult to treat. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) are the gold standards for treating MPM. Sometimes extreme cytoreductive surgery (eCRS) is required to achieve complete cytoreduction, which is one of the most important prognostic factors. There is limited information in the literature about the contribution of eCRS in patients with MPM. In this study, we aimed to investigate the impact of eCRS on survival and perioperative outcomes. Methods: The Department of Surgical Oncology at Cumhuriyet University database was retrospectively reviewed for MPM patients who underwent CRS-HIPEC between January 2004 and December 2018. Patients who underwent CRS-HIPEC were divided into eCRS and less extensive CRS (leCRS) groups. A resection of >= 5 organs or >= 3 small bowel anastomoses were defined as eCRS. Both groups were compared regarding survival, demographic information, and perioperative outcomes. Results: A total of 31 patients were included. eCRS-HIPEC was used in 15 patients. Complete cytoreduction (CC score 0/1) was achieved in all 31 patients. Compared to leCRS, the eCRS group had a longer median length of stay, longer intensive care unit stay, a higher median peritoneal cancer index (PCI), higher intraoperative blood loss, more frequent occurrence of any complication, and a longer operative time (all p values < 0.001). Clavien Dindo 3-4 complications, ASA, and gender were similar in both groups of patients (p > 0.05). It was found that there was no significant difference between the OS of the eCRS and leCRS groups (37.5 vs. 42.8 months, p = 0.895). Conclusions: Rates of serious complications and morbidity are similar in patients undergoing eCRS compared to leCRS. In patients with high PCI and multiorgan involvement, complete cytoreduction can be achieved by performing eCRS, and survival results equivalent to those with low PCI can be achieved.
dc.identifier.doi10.1080/00015458.2024.2301806
dc.identifier.endpage289
dc.identifier.issn0001-5458
dc.identifier.issn2577-0160
dc.identifier.issue4
dc.identifier.pmid38294331
dc.identifier.scopus2-s2.0-85185652178
dc.identifier.scopusqualityQ3
dc.identifier.startpage281
dc.identifier.urihttps://doi.org/10.1080/00015458.2024.2301806
dc.identifier.urihttps://hdl.handle.net/20.500.12418/29354
dc.identifier.volume124
dc.identifier.wosWOS:001162613600001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofActa Chirurgica Belgica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCytoreductive surgery
dc.subjectextreme cytoreductive surgery
dc.subjecthyperthermic intraperitoneal chemotherapy
dc.subjectmalign peritoneal mesothelioma
dc.subjectperitoneal cancer index
dc.titleIs extereme cytoreductive surgery beneficial to survival ın malignant peritoneal mesothelioma?
dc.typeArticle

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