Leptin/Melanocortin Pathway in Cholelithiasis Patients: A Diagnostic Perspective

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dc.authoridBOZTEPE GUCLU, GULSEN/0000-0002-3599-213X
dc.authoridSilig, Yavuz/0000-0002-0562-7457
dc.authoridTAS, Ayca/0000-0002-7132-1325
dc.contributor.authorAgbektas, Tugba
dc.contributor.authorGuclu, Gulsen
dc.contributor.authorTas, Ayca
dc.contributor.authorOzmen, Esma
dc.contributor.authorTopcu, Omer
dc.contributor.authorAydin, Suleyman
dc.contributor.authorSilig, Yavuz
dc.date.accessioned2025-05-04T16:45:53Z
dc.date.available2025-05-04T16:45:53Z
dc.date.issued2025
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractBackground: Cholelithiasis is the most prevalent inflammatory condition of the gallbladder. The regulation of biological processes, including energy homeostasis, and control of body weight are key mechanisms that the leptin and melanocortin pathways play a role in Cholelithiasis is the most prevalent inflammatory condition of the gallbladder. There are various risk factors for the development of gallstone disease, especially weight gain, and obesity is just one of them. This risk factor can be minimized by maintaining appetite and energy balance. Here, leptin and melanocortin pathways are the key mechanisms in maintaining appetite and energy homeostasis. Objectives: The aim of this study was to investigate the relationship between the levels of LEP, LEPR, TrkB, BDNF, POMC, and MC4R proteins in patients with Cholelithiasis. This study aims to determine the relationship between LEP, LEPR, TrkB, BDNF, POMC, and MC4R protein levels, which play a role in maintaining appetite and energy homeostasis, and cholelithiasis. Methods This study examined 44 patients diagnosed with Cholelithiasis and 44 healthy control subjects who had not previously been diagnosed with any form of Cholelithiasis. The levels of leptin (LEP), Leptin Binds To Leptin Receptors (LEPR), Tropomyosin Receptor Kinase B (TrkB), Brain-Derived Neurotrophic Factor (BDNF), Pro-OpioMelanoCortin (POMC), and Melanocortin-4 Receptors (MC4R) molecules were analyzed using the Enzyme-Linked Immunosorbent Assay (ELISA) method. The results were analyzed using the SPSS Software (Version 22.0) program and GraphPad Prism 8.0.1 software. Results: The study found a statistically significant decrease (p < 0.05) in MC4R, TrkB, BDNF, and POMC protein levels in Cholelithiasis patients compared to the control group. There was no statistically significant difference in LEP and LEPR concentration values between the two groups (p = 0.247, p = 0.674). Conclusion: The proteins MC4R, TrkB, BDNF, and POMC, which are involved in the leptin and melanocortin pathways may play a significant role in Cholelithiasis disease. However, more detailed research on the relevant proteins is needed. Nevertheless, this research will guide new studies.
dc.identifier.doi10.2174/0109298665343979241025114114
dc.identifier.endpage83
dc.identifier.issn0929-8665
dc.identifier.issn1875-5305
dc.identifier.issue1
dc.identifier.pmid39582225
dc.identifier.scopus2-s2.0-105003217385
dc.identifier.scopusqualityQ3
dc.identifier.startpage75
dc.identifier.urihttps://doi.org/10.2174/0109298665343979241025114114
dc.identifier.urihttps://hdl.handle.net/20.500.12418/35266
dc.identifier.volume32
dc.identifier.wosWOS:001437486900006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBentham Science Publ Ltd
dc.relation.ispartofProtein and Peptide Letters
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250504
dc.subjectCholelithiasis
dc.subjectleptin-melanocortin pathway
dc.subjectLEP
dc.subjectLEPR
dc.subjectTrkB
dc.subjectBDNF
dc.subjectPOMC
dc.subjectMC4R
dc.titleLeptin/Melanocortin Pathway in Cholelithiasis Patients: A Diagnostic Perspective
dc.typeArticle

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