Bioactive coatings on biopolymer materials: evaluation of mechanical, physical, thermal, and in vitro properties

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dc.authoridOKSUZ, Kerim Emre/0000-0001-7424-5930
dc.contributor.authorOksuz, Kerim Emre
dc.date.accessioned2024-10-26T18:02:42Z
dc.date.available2024-10-26T18:02:42Z
dc.date.issued2024
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractThe aim of this study was to develop and characterize coatings of bioglass nanoparticles (BGNs) on biopolymer (poly [glycolide-co-L-lactide], (PGLA)) surgical sutures, and to investigate the effects of these coatings on the performance of the sutures as they slid through a skin substitute. Melt-derived BGNs were used to coat resorbable PGLA biopolymers, providing them with bioactivity, biocompatibility, and improved physical and mechanical properties. The structural, thermal, and physical properties of the coated and uncoated biopolymers were analyzed using Differential Scanning Calorimetry (DSC), Fourier Transform Infrared Spectroscopy (FTIR), Field Emission Scanning Electron Microscopy (FE-SEM) and Energy-Dispersive X-ray Spectroscopy (EDXS). The dissolution profiles and bioactivity of the BGNs-coated PGLA biopolymers were assessed through Inductively Coupled Plasma Optical Emission Spectrometry (ICP-OES). Tensile strength tests were conducted on the biopolymers before and after immersion in simulated body fluid to evaluate the impact of the BGNs coating on the degradation of PGLA biopolymers. Incorporating BGNs into PGLA resulted in improved tensile strength properties. The study also found that increasing the BGNs ions content facilitated the formation of a hydroxycarbonate apatite (HCA) layer in Dulbecco's Modified Eagle Medium and medium with L-glutamine and sodium bicarbonate solutions. In vitro bioactivity tests demonstrated that the coated suture biopolymers exhibited enhanced attachment, migration, and proliferation of fibroblasts, indicating favorable biocompatibility of the biomaterial for clinical applications.
dc.description.sponsorshipSivas Cumhuriyet University
dc.description.sponsorshipNo Statement Available
dc.identifier.doi10.1007/s41779-024-01037-3
dc.identifier.endpage1280
dc.identifier.issn2510-1560
dc.identifier.issn2510-1579
dc.identifier.issue4
dc.identifier.scopus2-s2.0-85193700340
dc.identifier.scopusqualityQ3
dc.identifier.startpage1265
dc.identifier.urihttps://doi.org/10.1007/s41779-024-01037-3
dc.identifier.urihttps://hdl.handle.net/20.500.12418/28288
dc.identifier.volume60
dc.identifier.wosWOS:001228555200001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofJournal of the Australian Ceramic Society
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBiopolymers
dc.subjectCharacterization
dc.subjectBioactive coating
dc.subjectSoft tissue engineering
dc.subjectSurgical suture
dc.titleBioactive coatings on biopolymer materials: evaluation of mechanical, physical, thermal, and in vitro properties
dc.typeArticle

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