BSA/DNA binding behavior and the photophysicochemical properties of novel water soluble zinc(II)phthalocyanines directly substituted with piperazine groups

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dc.authoridBagda, Efkan/0000-0002-3925-3430
dc.contributor.authorKhezami, Khaoula
dc.contributor.authorHarmandar, Kevser
dc.contributor.authorBagda, Esra
dc.contributor.authorBagda, Efkan
dc.contributor.authorSahin, Gamze
dc.contributor.authorKarakodak, Nursen
dc.contributor.authorDurmus, Mahmut
dc.date.accessioned2024-10-26T18:09:03Z
dc.date.available2024-10-26T18:09:03Z
dc.date.issued2021
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractIn the current research, two novel zinc(II) phthalocyanines (ZnPcs) (1 and 2) directly connecting with 4-(4-methylpiperazin-1-yl)phenyl groups have been synthesized through the Suzuki-Miyaura coupling reaction. These ZnPcs 1 and 2 were converted to their water-soluble derivatives (1Q and 2Q) by quaternization. The photochemical and photophysical properties were determined in DMSO for the non-ionic zinc(II) phthalocyanines (1 and 2) and in both DMSO and aqueous solutions for the quaternized cationic derivatives (1Q and 2Q) to establish their photosensitizer capabilities in photodynamic therapy (PDT). The spectrofluorometric and spectrophotometric techniques were employed for the determination of interaction between water-soluble ZnPcs (1Q and 2Q) and BSA or ct-DNA. The binding constants of these compounds to BSA were found in the order of 10(8) M-1. The binding constant of the ct-DNA interaction with 2Q (1.09 x 10(5) M-1) was found higher than 1Q (6.87 x 10(4) M-1). The thermodynamic constants were determined for both 1Q and 2Q. The endothermic and spontaneous nature of interaction was observed with ct-DNA. Besides, the thermal denaturation and viscosity studies proved the non-intercalative mode of binding for both compounds to ct-DNA. [GRAPHICS] .
dc.identifier.doi10.1007/s00775-021-01868-6
dc.identifier.endpage465
dc.identifier.issn0949-8257
dc.identifier.issn1432-1327
dc.identifier.issue4
dc.identifier.pmid33944997
dc.identifier.scopus2-s2.0-85105971723
dc.identifier.scopusqualityQ2
dc.identifier.startpage455
dc.identifier.urihttps://doi.org/10.1007/s00775-021-01868-6
dc.identifier.urihttps://hdl.handle.net/20.500.12418/29926
dc.identifier.volume26
dc.identifier.wosWOS:000647031000001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofJournal of Biological Inorganic Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectZinc phthalocyanines
dc.subjectWater soluble
dc.subjectPhotodynamic therapy
dc.subjectBSA
dc.subjectDNA binding
dc.titleBSA/DNA binding behavior and the photophysicochemical properties of novel water soluble zinc(II)phthalocyanines directly substituted with piperazine groups
dc.typeArticle

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