Vascular graft infection by Staphylococcus aureus: efficacy of linezolid, teicoplanin and vancomycin systemic prophylaxis protocols in a rat model

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dc.contributor.authorAtahan, Erhan
dc.contributor.authorKatrancioglu, Nurkay
dc.contributor.authorOztop, Yasemin
dc.contributor.authorTuncer, Ersin
dc.contributor.authorOzer, Hatice
dc.contributor.authorManduz, Sinasi
dc.contributor.authorEngin, Aynur
dc.contributor.authorYalta, Tulin Deniz
dc.contributor.authorBerkan, Ocal
dc.contributor.authorDogan, Kasim
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T10:14:26Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T10:14:26Z
dc.date.issued2009
dc.department[Atahan, Erhan -- Katrancioglu, Nurkay -- Manduz, Sinasi -- Berkan, Ocal -- Dogan, Kasim] Cumhuriyet Univ, Sch Med, Dept Cardiovasc Surg, Sivas, Turkey -- [Oztop, Yasemin] Cumhuriyet Univ, Sch Med, Dept Microbiol, Sivas, Turkey -- [Tuncer, Ersin -- Ozer, Hatice] Cumhuriyet Univ, Sch Med, Dept Pathol, Sivas, Turkey -- [Engin, Aynur] Cumhuriyet Univ, Sch Med, Dept Clin Microbiol & Infect Dis, Sivas, Turkey -- [Yalta, Tulin Deniz] Sivas State Hosp, Dept Pathol, Sivas, Turkeyen_US
dc.description.abstractObjective: We investigated experimentally the in vivo prophylactic efficacies of linezolid, teicoplanin and vancomycin in subcutaneously implanted dacron graft infection caused by methicillin-resistant Staphylococcus aureus (MRSA). Materials and methods: Dacron grafts (1 cm(2)) were aseptically implanted into subcutaneous pockets that were surgically prepared in the backs of 50 rats. Ten of these rats were used as the control group (group I). Grafts in the remaining 40 rats were infected by inoculation of MRSA at the concentration of 2 x 10(7) colony-forming units (CFU)/ml. Ten of these rats constituted the contaminated, untreated group II. The other three study groups comprising 10 rats each were contaminated and then treated with linezolid (group III), teicoplanin (group IV) and vancomycin (group V), respectively. All rats were sacrificed and the grafts were removed after seven days and evaluated. Results: The bacterial count decreased in the rats from the groups treated with linezolid, teicoplanin and vancomycin. The linezolid and teicoplanin groups, however, showed a significantly lower bacterial number than the vancomycin group (p = 0.009 and p = 0.01). The intensity of inflammation was highest in the contaminated, untreated group, as expected. Conclusions: Single-dose linezolid, teicoplanin and vancomycin for peri-operative prophylaxis may prevent bacterial growth in vascular graft infections. The effect of linezolid and teicoplanin seemed similar and their effect was greater than that of vancomycin.en_US
dc.identifier.endpage125en_US
dc.identifier.issn1995-1892
dc.identifier.issue2en_US
dc.identifier.pmid19421648en_US
dc.identifier.scopus2-s2.0-67549094920en_US
dc.identifier.scopusqualityQ3
dc.identifier.startpage122en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12418/10174
dc.identifier.volume20en_US
dc.identifier.wosWOS:000266436900008en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCLINICS CARDIVE PUBL PTY LTDen_US
dc.relation.ispartofCARDIOVASCULAR JOURNAL OF AFRICAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleVascular graft infection by Staphylococcus aureus: efficacy of linezolid, teicoplanin and vancomycin systemic prophylaxis protocols in a rat modelen_US
dc.typeArticleen_US

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