Association between iron metabolism and SARS-COV-2 infection, determined by ferritin, hephaestin and hypoxia-induced factor-1 alpha levels in COVID-19 patients

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dc.authoridTEKIN, Yusuf Kenan/0000-0001-8047-4836
dc.authoridAydin, Huseyin/0000-0002-3194-830X
dc.authoridASLAN, ELIF SIBEL/0000-0002-3081-9004
dc.authoridKELES, SAMI/0000-0003-0177-3649
dc.authoridWhite, Kenneth/0000-0002-6103-9078
dc.contributor.authorAslan, Elif Sibel
dc.contributor.authorAydin, Hueseyin
dc.contributor.authorTekin, Yusuf Kenan
dc.contributor.authorKeles, Sami
dc.contributor.authorWhite, Kenneth N.
dc.contributor.authorHekim, Nezih
dc.date.accessioned2024-10-26T18:09:45Z
dc.date.available2024-10-26T18:09:45Z
dc.date.issued2023
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractBackground Due to the growing evidence of the importance of iron status in immune responses, the biomarkers of iron metabolism are of interest in novel Coronavirus Disease 2019 (COVID-19). The present prospective study was carried out to compare iron status indicated by levels of ferritin with the levels of two novel biomarkers related to iron homeostasis, hephaestin and hypoxia-inducible factors-1 (HIF-1 alpha) in the serum of patients with COVID-19 in comparison with a control group.Methods and results Blood samples from 34 COVID-19 patients and from 43 healthy volunteers were collected and the levels of HEPH and HIF-1 alpha were measured by ELISA and compared with levels of serum ferritin. COVID-19 patients had higher serum levels of ferritin than those levels in control group (P < 0.0001). Conversely levels of HIF-1 alpha and HEPH in the COVID-19 group were significantly lower than those of control group (P < 0.0001 for both). An inverse correlation between hephaestin and ferritin as well as between HIF-1 alpha and ferritin was found among all subjects (P < 0.0001), and among COVID-19 patients, but not to statistical significance.Conclusion Levels of hephaestin and HIF-1 alpha were found to be inversely related levels of ferritin across all participants in the study, and to our knowledge this is the first report of hephaestin and HIF-1 alpha as potential markers of iron status. Further studies are needed to corroborate the findings, utilizing a broader range of markers to monitor inflammatory as well as iron status.
dc.description.sponsorship[Biruni-BAP-2020-01-09]
dc.description.sponsorshipAcknowledgementsThanks for all authors and Biruni University for the grand support of project: Biruni-BAP-2020-01-09.
dc.identifier.doi10.1007/s11033-022-08221-3
dc.identifier.endpage2478
dc.identifier.issn0301-4851
dc.identifier.issn1573-4978
dc.identifier.issue3
dc.identifier.pmid36600108
dc.identifier.scopus2-s2.0-85145563051
dc.identifier.scopusqualityQ2
dc.identifier.startpage2471
dc.identifier.urihttps://doi.org/10.1007/s11033-022-08221-3
dc.identifier.urihttps://hdl.handle.net/20.500.12418/30263
dc.identifier.volume50
dc.identifier.wosWOS:000907795000001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofMolecular Biology Reports
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCOVID-19
dc.subjectHephaestin
dc.subjectHypoxia inducible factor 1-alfa (HIF-1 alpha)
dc.subjectIron metabolism
dc.subjectFerritin
dc.titleAssociation between iron metabolism and SARS-COV-2 infection, determined by ferritin, hephaestin and hypoxia-induced factor-1 alpha levels in COVID-19 patients
dc.typeArticle

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