Induction of ovulation using repeated doses of sulpiride, a dopamine antagonist, in ewe lambs
| dc.contributor.author | Kıvrak, Mehmet Buğra | |
| dc.contributor.author | Aydin, İbrahim | |
| dc.date.accessioned | 2024-03-11T12:00:11Z | |
| dc.date.available | 2024-03-11T12:00:11Z | |
| dc.date.issued | 2023 | tr |
| dc.department | Sağlık Bilimleri Enstitüsü | tr |
| dc.description.abstract | This study aimed to test the hypothesis that sulpiride can increase the concentration of circulating gonadotropin that can promote puberty in pre-pubertal ewe lambs. Here, 12 1–3- year- old Merino rams and 60 7–9- month- old Merino sheep were included in the study. The sheep were randomly divided into sulpiride (n = 30) and control (n = 30) groups. The sulpiride group was subcutaneously injected with 0.6 mg/ kg sulpiride twice daily (morning and evening) for 9 days. During these 9 days, blood samples were taken from the sheep before drug administration and at 4 h after every drug administration. The number of ovulating animals in the sulpiride group was significantly higher than that in the control group (90% vs. 32%). No oestrous signs were observed in either group during ram release. Further, there were no differences in the levels of mean follicle-stimulating hormone in the two groups based on treatment (p = .2), time (p = .3) or treatment-by- time interaction (p = .3). After sulpiride administration, the luteinizing hormone (LH) levels of the sulpiride group rapidly increased and remained stable for a long time, whereas physiological LH fluctuations in the control group remained unchanged. Within-group changes in terms of LH concentrations were significant for both groups (p < .001), whereas LH pulse frequency was significantly different between the sulpiride group (p = .03). Therefore, it is concluded that sulpiride can be used as a non-steroidal alternative to stimulate pre-pubertal ewe lambs and sheep during anoestrus. | tr |
| dc.identifier.pmid | 36369678 | en_US |
| dc.identifier.uri | https://hdl.handle.net/20.500.12418/15130 | |
| dc.identifier.wos | WOS:000892014500001 | en_US |
| dc.identifier.wosquality | Q2 | |
| dc.indekslendigikaynak | Web of Science | en_US |
| dc.indekslendigikaynak | PubMed | en_US |
| dc.language.iso | en | en_US |
| dc.relation.publicationcategory | Rapor | tr |
| dc.rights | info:eu-repo/semantics/openAccess | tr |
| dc.title | Induction of ovulation using repeated doses of sulpiride, a dopamine antagonist, in ewe lambs | en_US |
| dc.type | Article | en_US |
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