Drug delivery behavior of magnetic composite: In vitro study

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dc.contributor.authorAkkaya, Birnur
dc.contributor.authorYerliyurt, Beyza Nur
dc.date.accessioned2024-10-26T18:03:42Z
dc.date.available2024-10-26T18:03:42Z
dc.date.issued2024
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractBackground One method for delivering the medication to the intended location and achieving the desired therapeutic effect is controlled drug release. Compared to typical release systems, controlled medication release systems offer fewer potential adverse effects and can increase patient comfort by prolonging the time intervals between drug intakes. Expanded perlite modified composite were used as drug carrier materials in the current investigation because of its excellent adsorption capability. Aim: Using magnetic poly(hydroxyethylmethacrylate-expanded perlite) (m-p(hema-ep)) composite material, doxorubicin release was examined in this work. Methodolgy First, a magnetic p(hema-ep) composite was created for this purpose and examined using SEM, FTIR, and swelling tests. The medication doxorubicin served as a model. Tests for reusability were conducted. The synthesized magnetic p(hema-ep) composite was shown to be capable of being recycled ten times without losing effectiveness. On the C6 cell line, the material and the material that had been loaded with doxorubicin were subjected to cytotoxicity tests under magnetic field. Results The impacts of variables like pH, time, temperature, on drug release were examined as a consequence of the characterisation procedure. The ideal release parameters were found to be 80% release at pH 4.5, 70% release is seen at 7.4, and temperature 22 degrees C, under magnetic field. Conclusion: The anti-cancer medication doxorubicin (Dox) was used as a model drug because it is widely used in cancer treatment and is simple to quantify using methods like UV-visible spectroscopy. There are enhanced doxorubicin release under magnetic field.
dc.description.sponsorshipTUBITAK [221Z344]
dc.description.sponsorshipThis manuscript is supported by TUBITAK 221Z344 numbered Project.
dc.identifier.endpage675
dc.identifier.issn2223-4721
dc.identifier.issn2076-0299
dc.identifier.issue3
dc.identifier.scopus2-s2.0-85201590931
dc.identifier.scopusqualityQ4
dc.identifier.startpage666
dc.identifier.urihttps://hdl.handle.net/20.500.12418/28511
dc.identifier.volume23
dc.identifier.wosWOS:001284667800012
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherIbn Sina Trust
dc.relation.ispartofBangladesh Journal of Medical Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectComposite
dc.subjectdrug release
dc.subjectmagnetic field
dc.subjectexpanded perlite.
dc.titleDrug delivery behavior of magnetic composite: In vitro study
dc.typeArticle

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