The role of nitric oxide in anticonvulsant effects of lycopene supplementation on pentylenetetrazole-induced epileptic seizures in rats

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dc.authoridTaskiran, Ahmet Sevki/0000-0002-5810-8415
dc.contributor.authorTaskiran, Ahmet Sevki
dc.contributor.authorTastemur, Yasar
dc.date.accessioned2024-10-26T18:04:04Z
dc.date.available2024-10-26T18:04:04Z
dc.date.issued2021
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractRecent studies have shown that natural antioxidant compounds have positive effects on the nervous system. Lycopene, the red pigment in tomatoes, is one of the potent natural antioxidants, and is used as supplementation because of its well-known health benefits. However, its effect on epileptic seizures and underlying mechanisms are still unclear. In this study, it was aimed to investigate the effect of lycopene on pentylenetetrazole-induced epileptic seizures in rats and to elucidate the nitric oxide pathway in this effect. In this study, thirty male Wistar albino rats were used. Animals were divided into five groups (n = 6 for each group) as control, saline (1 mL/kg/day serum physiologic), positive control (2 mg/kg/day diazepam), and lycopene (5 and 10 mg/kg/day) for ten days. Pentylenetetrazole (45 mg/kg) was given to induce a seizure in the tenth day except for the control. Passive avoidance test was carried out to evaluate memory function. Inducible nitric oxide synthase (iNOS), neuronal nitric oxide synthase (nNOS), and nitric oxide (NO) levels were measured in the cortex and hippocampal brain regions using the ELISA kits. Lycopene supplementation prolonged epileptic seizure onset times and reduced seizure stages. Besides, lycopene supplementation improved memory impairment after seizures. Moreover, lycopene significantly reduced the level of iNOS, nNOS, and NO in the brain. Lycopene supplementation significantly alleviated seizures and memory impairment. Its anticonvulsive effect could be associated with the nitric oxide pathway. Lycopene supplementation could be useful as a supportive therapeutic agent in epileptic patients.
dc.identifier.doi10.1007/s00221-020-06012-5
dc.identifier.endpage599
dc.identifier.issn0014-4819
dc.identifier.issn1432-1106
dc.identifier.issue2
dc.identifier.pmid33385251
dc.identifier.scopus2-s2.0-85098510955
dc.identifier.scopusqualityQ3
dc.identifier.startpage591
dc.identifier.urihttps://doi.org/10.1007/s00221-020-06012-5
dc.identifier.urihttps://hdl.handle.net/20.500.12418/28732
dc.identifier.volume239
dc.identifier.wosWOS:000604074200001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofExperimental Brain Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectEpilepsy
dc.subjectPentylenetetrazole
dc.subjectLycopene
dc.subjectNitric oxide
dc.subjectRats
dc.titleThe role of nitric oxide in anticonvulsant effects of lycopene supplementation on pentylenetetrazole-induced epileptic seizures in rats
dc.typeArticle

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