Synthesis, computational analyses, antibacterial and antibiofilm properties of nicotinamide derivatives

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dc.authorid0000-0002-7282-4928tr
dc.contributor.authorTaşkın Kafa, Ayşe Hümeyra
dc.contributor.authorTüzün, Gamze
dc.contributor.authorGüney, Elif
dc.contributor.authorAslan, Rukiye
dc.contributor.authorSayın, Koray
dc.contributor.authorTüzün,Burak
dc.contributor.authorAtaseven, Hilmi
dc.date.accessioned2023-06-22T12:04:54Z
dc.date.available2023-06-22T12:04:54Z
dc.date.issuedAğustos 2022tr
dc.departmentTıp Fakültesitr
dc.description.abstractNewly designed nicotinamide derivatives were synthesized and characterized using spectral techniques (IR, 1H-NMR, 13C-NMR, and MS). Moreover, these compounds are investigated computationally. B3LYP/6–31 + G(d,p) level is selected as the calculation level in this study. Experimental and calculated IR spectrum were compared to each other. Electronic properties of synthesized compounds are examined using HOMO/LUMO contour plot and MEP maps. Antibacterial activity and antibiofilm properties are investigated experimentally. Additionally, antibacterial properties of studied compounds are investigated by molecular docking analyses. As a result, ND4 was found as the best inhibitor candidate against Enterococcus faecalis.tr
dc.identifier.scopus2-s2.0-85127576509en_US
dc.identifier.scopusqualityN/A
dc.identifier.urihttps://hdl.handle.net/20.500.12418/13965
dc.identifier.wosWOS:000778056600004en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıtr
dc.rightsinfo:eu-repo/semantics/openAccesstr
dc.titleSynthesis, computational analyses, antibacterial and antibiofilm properties of nicotinamide derivativesen_US
dc.typeArticleen_US

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