Silver(I)-N-heterocyclic carbene complexes challenge cancer; evaluation of their anticancer properties and in silico studies

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dc.authoridKilickaya, Ozan/0000-0003-2710-2149
dc.authoridSahin-Bolukbasi, Serap/0000-0003-1057-2558
dc.authoridCanturk, Pakize/0000-0001-8623-784X
dc.contributor.authorSahin-Bolukbasi, Serap
dc.contributor.authorCanturk-Kilickaya, Pakize
dc.contributor.authorKilickaya, Ozan
dc.date.accessioned2024-10-26T18:02:37Z
dc.date.available2024-10-26T18:02:37Z
dc.date.issued2021
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractBecause of the continuous need for efficient therapeutic agents against various kinds of cancers and infectious diseases, the pharmaceutical industry has to find new candidates and strategies to develop novel and efficient drugs. They increasingly use computational tools in R&D stages for screening extensive sets of drug candidates before starting pre-clinical and clinical trials. N-Heterocyclic carbenes (NHCs) can be evaluated as good drug candidates because they offer both anti-cancer and anti-inflammatory features with their general low-toxicity profiles. To date, different kinds of NHCs (Cu, Co, Ni, Au, Ag, Ru, etc.) have been synthesized and their therapeutic uses has been shown. Here, we have reviewed the recent studies focused on Ag(I)-NHC complexes and their anti-cancer activities. Also, existing examples of the usage of density functional theory and structure-activity relationship have been evaluated.
dc.identifier.doi10.1002/ddr.21822
dc.identifier.endpage926
dc.identifier.issn0272-4391
dc.identifier.issn1098-2299
dc.identifier.issue7
dc.identifier.pmid33978961
dc.identifier.scopus2-s2.0-85105611613
dc.identifier.scopusqualityQ2
dc.identifier.startpage907
dc.identifier.urihttps://doi.org/10.1002/ddr.21822
dc.identifier.urihttps://hdl.handle.net/20.500.12418/28266
dc.identifier.volume82
dc.identifier.wosWOS:000649441900001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofDrug Development Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectanticancer activity
dc.subjectDFT
dc.subjectN? heterocyclic carbine
dc.subjectSAR
dc.subjectsilver complex
dc.titleSilver(I)-N-heterocyclic carbene complexes challenge cancer; evaluation of their anticancer properties and in silico studies
dc.typeReview Article

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