Radiotherapy Results in Locally Advanced Sinonasal Cancer

Basit Öğe Kaydı
dc.authoridDelikgoz Soykut, Ela/0000-0003-1225-8458
dc.contributor.authorBirgi, Sumerya Duru
dc.contributor.authorAkaguenduez, Ozlem Ozkaya
dc.contributor.authorDagdelen, Meltem
dc.contributor.authorYazici, Gozde
dc.contributor.authorCanyilmaz, Emine
dc.contributor.authorBicakci, Beyhan Ceylaner
dc.contributor.authorCetinayak, Hasan O.
dc.date.accessioned2024-10-26T18:11:43Z
dc.date.available2024-10-26T18:11:43Z
dc.date.issued2024
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractObjectives:This study aims to examine the treatment outcomes and related factors in locally advanced sinonasal cancer across Turkiye.Methods:Twelve centers participants of the Turkish Society for Radiation Oncology Head and Neck Study Group attended the study. One hundred and ninety-four patients treated with intensity-modulated radiation therapy between 2001 and 2021 were analyzed retrospectively. The survival analysis was performed using the Kaplan-Meier method. Acute and late toxicity were recorded per Common Toxicity Criteria for Adverse Events V4.0.Results:The median age was 58 years and 70% were male. The majority of tumors were located in maxillary sinus (59%). Most of the patients (%83) had T3 and T4A disease. Fifty-three percent of patients were in stage 4A. Radiotherapy was administered to 80% of the patients in the adjuvant settings. Median 66 Gy dose was administered in median 31 fractions. Chemotherapy was administered concomitantly with radiotherapy in 45% of the patients mostly with weekly cisplatin. No grade >= 4 acute and late toxicity was observed. The median follow-up was 43 months. The 5-year and 10-year overall survival (OS); locoregional recurrence-free survival (LRFS); distant metastasis-free survival (DMFS), and progression-free survival (PFS) rates were 61% and 47%; 69% and 61%; 72%, and 69%, and 56% and 49%, respectively. In the multivariate analysis, several factors demonstrated significant influence on OS, such as performance status, surgery, and lymph node involvement. Moreover, surgery was the key prognostic factor for LRFS. For DMFS, lymph node involvement and surgical margin were found to be influential factors. In addition, performance status and lymph node involvement were identified as significantly affecting PFS.Conclusions:In our study, the authors obtained promising results with IMRT. Performance status, lymph node involvement, and surgery emerged as the primary factors significantly influencing OS.
dc.identifier.doi10.1097/COC.0000000000001089
dc.identifier.endpage288
dc.identifier.issn0277-3732
dc.identifier.issn1537-453X
dc.identifier.issue6
dc.identifier.scopus2-s2.0-85194112209
dc.identifier.scopusqualityQ2
dc.identifier.startpage279
dc.identifier.urihttps://doi.org/10.1097/COC.0000000000001089
dc.identifier.urihttps://hdl.handle.net/20.500.12418/30777
dc.identifier.volume47
dc.identifier.wosWOS:001278993100005
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofAmerican Journal of Clinical Oncology-Cancer Clinical Trials
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectparanasal sinus cancer
dc.subjectsurgery
dc.subjectchemoradiotherapy
dc.subjectintensity-modulated radiotherapy
dc.titleRadiotherapy Results in Locally Advanced Sinonasal Cancer
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu