Does mean platelet volume influence the attack or attack-free period in the patients with Familial Mediterranean fever?

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dc.contributor.authorSahin, Safak
dc.contributor.authorSenel, Soner
dc.contributor.authorAtaseven, Hilmi
dc.contributor.authorYalcin, Ilker
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T10:03:10Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T10:03:10Z
dc.date.issued2013
dc.department[Sahin, Safak] Gaziosmanpasa Univ, Fac Med, Dept Internal Med, Tokat, Turkey -- [Senel, Soner] Erciyes Univ, Fac Med, Dept Rheumatol, Kayseri, Turkey -- [Ataseven, Hilmi] Cumhuriyet Univ, Fac Med, Dept Gastroenterol, Sivas, Turkey -- [Yalcin, Ilker] Gurun State Hosp, Dept Internal Med, Sivas, Turkeyen_US
dc.description.abstractFamilial Mediterranean fever (FMF) is an autosomal recessive hereditary disease which is characterized by recurrent attacks of fever and peritonitis, pleuritis, arthritis, or erysipelas-like skin disease. Mean platelet volume (MPV) is a sign of platelet activation. There are limited studies in the literature about MPV levels in FMF patients. We aimed to investigate MPV levels during the attack period (group 1) and attack-free periods (group 2) in FMF patients, and to compare them with healthy controls (group 3). The study consisted of the data of: 60 group 1 patients, 120 group 2 patients, and 75 group 3 patients. Erythrocyte sedimentation rate, C-reactive protein, white blood cell count, platelet count, and MPV levels were retrospectively recorded from patient files. Statistical analyses showed that MPV was significantly lower in FMF patients both in group 1 and group 2 than in group 3 (p = 0.004, p = 0.002, respectively); however, there was no difference among group 1 and group 2 in patients with FMF (p = 0.279). The mean platelet count of group 1 was higher than that of group 3 (p = 0.010). In conclusion, this study results suggested that MPV level did not increase on the contrary, it decreased in patients with FMF both in group 1 and/or group 2 when compared to group 3. It was concluded that the lower MPV level was an expected result of secondary thrombocytosis in FMF patients.en_US
dc.identifier.doi10.3109/09537104.2012.697591en_US
dc.identifier.endpage323en_US
dc.identifier.issn0953-7104
dc.identifier.issue4en_US
dc.identifier.pmid22720903en_US
dc.identifier.scopus2-s2.0-84876113135en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpage320en_US
dc.identifier.urihttps://dx.doi.org/10.3109/09537104.2012.697591
dc.identifier.urihttps://hdl.handle.net/20.500.12418/8893
dc.identifier.volume24en_US
dc.identifier.wosWOS:000317501800012en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherINFORMA HEALTHCAREen_US
dc.relation.ispartofPLATELETSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFamilial Mediterranean feveren_US
dc.subjectmean platelet volumeen_US
dc.subjectplatelet activationen_US
dc.subjectattacken_US
dc.titleDoes mean platelet volume influence the attack or attack-free period in the patients with Familial Mediterranean fever?en_US
dc.typeArticleen_US

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