Ursolic acid: a natural modulator of signaling networks in different cancers

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dc.authoridSharifi-Rad, Javad/0000-0002-7301-8151
dc.authoridKhan, Khushbukhat/0000-0002-9946-9057
dc.authoridRahman, Anees/0009-0003-8285-6717
dc.authoridBUTNARIU, Monica/0000-0002-2032-5000
dc.contributor.authorZafar, Sameen
dc.contributor.authorKhan, Khushbukhat
dc.contributor.authorHafeez, Amna
dc.contributor.authorIrfan, Muhammad
dc.contributor.authorArmaghan, Muhammad
dc.contributor.authorRahman, Anees Ur
dc.contributor.authorGurer, Eda Sonmez
dc.date.accessioned2024-10-26T18:11:04Z
dc.date.available2024-10-26T18:11:04Z
dc.date.issued2022
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractIncidence rate of cancer is estimated to increase by 40% in 2030. Furthermore, the development of resistance against currently available treatment strategies has contributed to the cancer-associated mortality. Scientists are now looking for the solutions that could help prevent the disease occurrence and could provide a pain-free treatment alternative for cancers. Therefore, efforts are now put to find a potent natural compound that could sever this purpose. Ursolic acid (UA), a triterpene acid, has potential to inhibit the tumor progression and induce sensitization to conventional treatment drugs has been documented. Though, UA is a hydrophobic compound therefore it is usually chemically modified to increase its bioavailability prior to administration. However, a thorough literature indicating its mechanism of action and limitations for its use at clinical level was not reviewed. Therefore, the current study was designed to highlight the potential mechanism of UA, its anti-cancer properties, and potential applications as therapeutic compound. This endeavour is a valuable contribution in understanding the hurdles preventing the translation of its potential at clinical level and provides foundations to design new studies that could help enhance its bioavailability and anti-cancer potential for various cancers.
dc.identifier.doi10.1186/s12935-022-02804-7
dc.identifier.issn1475-2867
dc.identifier.issue1
dc.identifier.pmid36496432
dc.identifier.scopus2-s2.0-85143656008
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1186/s12935-022-02804-7
dc.identifier.urihttps://hdl.handle.net/20.500.12418/30494
dc.identifier.volume22
dc.identifier.wosWOS:000897505200002
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBmc
dc.relation.ispartofCancer Cell International
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectUrsolic acid
dc.subjectNatural compound
dc.subjectDrug resistance
dc.subjectCell signaling
dc.subjectAnti-cancer potential
dc.titleUrsolic acid: a natural modulator of signaling networks in different cancers
dc.typeReview Article

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