Relationship between homocysteine and non-dipper pattern in patients with type 2 diabetes mellitus

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dc.contributor.authorKorkmaz, Serdal
dc.contributor.authorYilmaz, Abdulkerim
dc.contributor.authorYildiz, Gursel
dc.contributor.authorKilicli, Fatih
dc.contributor.authorIcagasioglu, Serhat
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T10:03:33Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T10:03:33Z
dc.date.issued2012
dc.department[Korkmaz, Serdal] Cumhuriyet Univ, Sch Med, Div Hematol, Sivas, Turkey -- [Yilmaz, Abdulkerim] Gaziosmanpasa Univ, Sch Med, Div Gastroenterol, Tokat, Turkey -- [Yildiz, Gursel] Ataturk State Hosp, Clin Nephrol, Zongudak, Turkey -- [Kilicli, Fatih] Cumhuriyet Univ, Sch Med, Div Endocrinol, Sivas, Turkey -- [Icagasioglu, Serhat] Cumhuriyet Univ, Sch Med, Dept Internal Med, Sivas, Turkeyen_US
dc.description.abstractObjective: The rate of reduction of nocturnal blood pressure (NBP) is lesser than normal in patients with type 2 diabetes mellitus (type 2 DM). Hyperhomocysteinemia (HHC) disrupts vascular structure and function, no matter the underlying causes. The risk of development of vascular disease is greater in diabetic patients with hyperhomocysteinemia than in patients with normal homocystein levels. The aim of the study was to investigate whether there are differences of homocystein levels in dipper and non-dippers patients with type 2 DM. Subjects and methods: We compared 50 patients (33 females, 17 males) with type 2 DM and 35 healthy individuals (18 females, 17 males 1 in a control group. Ambulatory blood pressure monitoring (ABPM) was performed and homocysteine levels were measured in all patients. Results: We found that the percentage of non-dipper pattern was 72% in patients with type 2 DM and 57% in control group. In diabetic and control individuals, homocystein levels were higher in non-dipper (respectively 13.4 +/- 8.1 mu mol/L and 11.8 +/- 5 mu mol/L) than in dipper subjects (respectively, 11.8 +/- 5.8 mu mol/L and 10.1 +/- 4.2 mu mol/L), but there was no significant difference between the two groups (respectively, p = 0.545, p = 0.294). Conclusion: In both groups, homocystein levels were higher in non-dipper than in dipper participants, but there was no significant difference between the groups. High homocystein levels and the non-dipper pattern increases cardiovascular risk. Therefore, the relationship between nocturnal blood pressure changes and homocystein levels should be investigated in a larger study. Arq Bras Endocrinol Metab 2012;56(5):285-90en_US
dc.identifier.doi10.1590/S0004-27302012000500002en_US
dc.identifier.endpage290en_US
dc.identifier.issn0004-2730
dc.identifier.issue5en_US
dc.identifier.pmid22911280en_US
dc.identifier.scopus2-s2.0-84865350172en_US
dc.identifier.scopusqualityN/A
dc.identifier.startpage285en_US
dc.identifier.urihttps://dx.doi.org/10.1590/S0004-27302012000500002
dc.identifier.urihttps://hdl.handle.net/20.500.12418/9076
dc.identifier.volume56en_US
dc.identifier.wosWOS:000308686600002en_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSBEM-SOC BRASIL ENDOCRINOLOGIA & METABOLOGIAen_US
dc.relation.ispartofARQUIVOS BRASILEIROS DE ENDOCRINOLOGIA E METABOLOGIAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHomocysteinen_US
dc.subjectnocturnal blood pressureen_US
dc.subjectnon-dipper phenomenonen_US
dc.subjectdiabetes mellitus type 2en_US
dc.titleRelationship between homocysteine and non-dipper pattern in patients with type 2 diabetes mellitusen_US
dc.typeArticleen_US

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