Examining the Early Period Effect of Nilotinib on Hearing: An Experimental Study

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dc.contributor.authorBora, Adem
dc.contributor.authorDurmus, Kasim
dc.contributor.authorTerzi, Hatice
dc.contributor.authorAltuntas, Emine Elif
dc.date.accessioned2024-10-26T18:05:28Z
dc.date.available2024-10-26T18:05:28Z
dc.date.issued2020
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractOBJECTIVES: Nilotinib has very few side effects, including neutropenia, thrombocytopenia, cardiotoxicity, high pancreatic lipase, ischemia, and vascular occlusion. We aimed to investigate whether short-term administration of nilotinib had ototoxic effects in rats. MATERIALS and METHODS: Wistar-albino rats were categorized into three groups: group C (administered 0.25 mL of distilled water, no nilotinib), group N-20 (administered 20 mg/kg/day of nilotinib dissolved in distilled water), and group N-50 (administered 50 mg/kg/day of nilotinib dissolved in distilled water). A single dose was administered once per day, at the same hour, over 21 days. Auditory brainstem response (ABR) thresholds were recorded on day 0 and day 21. RESULTS: There were no changes in ABR threshold values obtained on day 0 (baseline) and on day 21 across all three groups. A statistically significant difference was not found in terms of the mean latency of waves V and III, interpeak latency values of waves III-V, and amplitude ratios of waves III-V and V/Va at baseline and on day 21 across all three groups on within-group or between-group evaluation. CONCLUSION: Consequently, further studies are needed that involve different drug doses, prolonged administration of drugs, as well as distortion otoacoustic emission test for the evaluation of cochlear activation and ABR. Furthermore, histopathological studies are needed to indicate whether the cochlea is affected to prove that nilotinib has definitively no ototoxic effect.
dc.identifier.doi10.5152/iao.2019.5908
dc.identifier.endpage86
dc.identifier.issn1308-7649
dc.identifier.issn2148-3817
dc.identifier.issue1
dc.identifier.pmid31287435
dc.identifier.scopus2-s2.0-85083514011
dc.identifier.scopusqualityQ3
dc.identifier.startpage77
dc.identifier.urihttps://doi.org/10.5152/iao.2019.5908
dc.identifier.urihttps://hdl.handle.net/20.500.12418/29012
dc.identifier.volume16
dc.identifier.wosWOS:000531858400017
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAves
dc.relation.ispartofJournal of International Advanced Otology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectNilotinib
dc.subjectototoxicity
dc.subjectrat
dc.subjectauditory brain stem response
dc.titleExamining the Early Period Effect of Nilotinib on Hearing: An Experimental Study
dc.typeArticle

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