Effects of a single intravaneous dose of zoledronic acid on bone healing following tooth extraction in ovariectomized rabbits

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dc.authoridhocaoglu, turgay peyami/0000-0002-0281-8928
dc.contributor.authorMavi, Esra
dc.contributor.authorHocaoglu, Peyami Turgay
dc.date.accessioned2024-10-26T18:06:05Z
dc.date.available2024-10-26T18:06:05Z
dc.date.issued2020
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractObjective: The present study is aimed to investigate the effects of administering a single intravenous dose of zoledronic acid (ZA) on bone healing following tooth extraction in ovariectomized rabbits. Materials and methods: Female, New Zealand rabbits were randomly divided into three groups including Control, ovariectomy + saline (OVX) and ovariectomy + zoledronic acid group (ZOL). Bilateral ovariectomy was performed to the rabbits in OVX and ZOL groups under general anesthesia. Control group underwent sham surgery. Eight weeks later, mandibular right incisors of all animals were extracted under general anesthesia. Before the procedure, Control and OVX groups were given saline and 0.1 mg/kg ZA was administered to ZOL group intravenously. All animals were sacrificed after 12 weeks. Results: The findings of histopathological and biochemical evaluations reflected insignificant differences among study groups in vascular endothelial growth factor (VEGF), increases in osteoclasts, ossification, vascularization and mononuclear cell infiltration measures (p > 0.05). In contrast, bone morphogenic protein 2 (BMP-2), tumor necrosis factor alpha (TNF-alpha) and organization of the extraction wound differed significantly between groups (p < 0.05) Conclusion: The potential beneficial effects of ZA administration on the wound healing process following tooth extraction were demonstrated via serum TNF-alpha, BMP-2 and VEGF levels in an osteoporotic model in ovariectomized rabbits. (C) 2020 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University.
dc.identifier.doi10.1016/j.sdentj.2020.03.016
dc.identifier.endpage730
dc.identifier.issn1013-9052
dc.identifier.issn1658-3558
dc.identifier.issue7
dc.identifier.pmid34803326
dc.identifier.scopus2-s2.0-85083110259
dc.identifier.scopusqualityQ2
dc.identifier.startpage724
dc.identifier.urihttps://doi.org/10.1016/j.sdentj.2020.03.016
dc.identifier.urihttps://hdl.handle.net/20.500.12418/29353
dc.identifier.volume33
dc.identifier.wosWOS:000718989500002
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofSaudi Dental Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBisphosphonates
dc.subjectZoledronic acid
dc.subjectOvariectomy
dc.subjectTooth extraction
dc.titleEffects of a single intravaneous dose of zoledronic acid on bone healing following tooth extraction in ovariectomized rabbits
dc.typeArticle

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