Potassium Ion Channel Protein (KCNH) Levels in Patients with Fibromyalgia Syndrome

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dc.authorid0000-0002-0562-7457tr
dc.contributor.authorTaş, Ayça
dc.contributor.authorHayta, Emrullah
dc.contributor.authorKaradağ, Ahmet
dc.contributor.authorZontul, Cemile
dc.contributor.authorÖzmen, Esma
dc.contributor.authorAydın, Süleyman
dc.contributor.authorSiliğ, Yavuz
dc.date.accessioned2022-05-16T08:42:46Z
dc.date.available2022-05-16T08:42:46Z
dc.date.issued2021tr
dc.departmentTıp Fakültesitr
dc.description.abstractAlthough there is not yet full clarity of the pathogenesis of fibromyalgia syndrome (FM), central sensitization is considered to be responsible. The purpose of this study was to measure the plasma levels of potassium ion channel proteins (human KCNH2, KCNH6 and KCNH7) in FM patients and healthy control subjects. The study sample includes 76 newly diagnosed FM patients and 79 healthy individuals. Venous blood samples were taken to measure the plasma levels of KCNH2, KCNH6 and KCNH7. Pain severity in FM patients was assessed using a visual analog scale (VAS). Bioinformatics analysis was performed using the STRING v 11 Protein interaction tool. Age, gender and body mass index were seen to be similar in both groups. In comparisons between FM and control groups, KCNH2 plasma levels was found to be significantly lower in the FM group. No significant correlation was found between plasma levels of KCNH2, KCNH6 and KCNH7 protein levels and VAS score of patients with FM. The KCNH2 protein had a high homology score with 9 proteins. The plasma levels of KCNH2 FM patients were found to be lower than those of the healthy control subjects, no difference was determined in respect of the plasma levels of KCNH6 and KCNH7. These results may be of use in guiding future studies on the pathogenesis of FM.tr
dc.identifier.citation1Department of Nutrition and Diet, Faculty of Health Sciences, Sivas Cumhuriyet University, Sivas, Turkey 2Department of Physical Therapy and Rehabilitation, Faculty of Medicine, Acıbadem University, İstanbul, Turkey 3Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Sivas Cumhuriyet University, Sivas, Turkey 4Department of Chemistry and Chemical Processing Technologies Services, Yıldızeli Vocational School, Sivas, Turkey 5Department of Biochemistry, Nigde Omer Halis Demir University, Faculty of Medicine, Niğde, Turkey 6Department of Medical Biochemistry and Clinical Biochemistry, Faculty of Medicine, Fırat University, Elazığ, Turkey 7Department of Biochemistry, Faculty of Medicine, Sivas Cumhuriyet University, Sivas, Turkeytr
dc.identifier.doi10.14715/cmb/2021.67.5.57en_US
dc.identifier.endpage457tr
dc.identifier.issue5tr
dc.identifier.pmid35818223en_US
dc.identifier.scopus2-s2.0-85124946827en_US
dc.identifier.scopusqualityN/A
dc.identifier.startpage451tr
dc.identifier.urihttps://hdl.handle.net/20.500.12418/13125
dc.identifier.volume67tr
dc.identifier.wosWOS:000752871500025en_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCMB Association Publihertr
dc.relation.ispartofCellular and Molecular Biologyen_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıtr
dc.rightsinfo:eu-repo/semantics/openAccesstr
dc.subjectPotassium ion channel, fibromyalgia, KCNH2, KCNH6 and KCNH7tr
dc.titlePotassium Ion Channel Protein (KCNH) Levels in Patients with Fibromyalgia Syndromeen_US
dc.typeArticleen_US

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