The effect of cardiac resynchronization therapy on arterial stiffness and central hemodynamic parameters

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dc.authoridCoksevim, Metin/0000-0001-6907-6941
dc.authoridYuksel, Serkan/0000-0001-9501-4568
dc.authoridcerik, idris bugra/0000-0003-1419-3950
dc.authoridYenercag, Mustafa/0000-0002-0933-7852
dc.contributor.authorCoksevim, Metin
dc.contributor.authorAkcay, Murat
dc.contributor.authorYuksel, Serkan
dc.contributor.authorYenercag, Mustafa
dc.contributor.authorCerik, Bugra
dc.contributor.authorGedikli, Omer
dc.contributor.authorGulel, Okan
dc.date.accessioned2024-10-26T18:09:38Z
dc.date.available2024-10-26T18:09:38Z
dc.date.issued2020
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractIntroduction: Cardiac resynchronization therapy (CRT) is a device-based method of treatment which decreases morbidity and mortality in heart failure with reduced ejection fraction (HFrEF). This study was aimed to investigate the effects of CRT on hemodynamic and arterial stiffness parameters evaluated by noninvasive method, and determine whether there is a correlation between the changes after CRT in these parameters and the clinical response to CRT or not. Methods: The study included 46 patients with HFrEF who were planned to undergo CRT implantation. Before the CRT implantation, clinical and demographic data were recorded from all patients. Hemodynamic and arterial stiffness parameters were measured oscillometrically by an arteriograph before CRT implantation. The patients were re-evaluated minimum three months after CRT; the above-mentioned parameters were measured again and compared to the pre-CRT period. Results: Compared to the period before CRT, mean systolic blood pressure (SBP) (116.8 +/- 19.1 mm Hg vs 127.7 +/- 20.9 mm Hg, P = .005), central SBP (cSBP) (106.2 +/- 17.3 mm Hg vs 116.8 +/- 18.7 mm Hg, P = .015), cardiac output (CO) (4.6 +/- 0.8 lt/min vs 5.1 +/- 0.8 lt/min, P = .002), stroke volume (65.6 +/- 16.3 mL vs 72.0 +/- 14.9 mL), and pulse wave velocity (PWV) (10 +/- 1.6 m/sec vs 10.4 +/- 1.8 m/sec, P = .004) increased significantly in post-CRT period. In addition, the same parameters were significantly increased post-CRT period in patients with clinical response. However, there was not any similar increase in nonresponder patients. Conclusion: This study demonstrated that SBP, CO, and PWV increased significantly after CRT. The modest increases in these parameters were observed to be associated with positive clinical outcomes.
dc.identifier.doi10.1002/joa3.12331
dc.identifier.endpage507
dc.identifier.issn1880-4276
dc.identifier.issn1883-2148
dc.identifier.issue3
dc.identifier.pmid32528578
dc.identifier.scopus2-s2.0-85081754170
dc.identifier.scopusqualityQ2
dc.identifier.startpage498
dc.identifier.urihttps://doi.org/10.1002/joa3.12331
dc.identifier.urihttps://hdl.handle.net/20.500.12418/30191
dc.identifier.volume36
dc.identifier.wosWOS:000538684800017
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Arrhythmia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectcardiac response
dc.subjectcardiac resynchronization therapy
dc.subjectcongestive heart failure
dc.subjecthemodynamics parameters
dc.subjectpulse wave velocity
dc.titleThe effect of cardiac resynchronization therapy on arterial stiffness and central hemodynamic parameters
dc.typeArticle

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