The effect of magnesium sulfate on memory and anxiety-like behavior in a rat model: an investigation of its neuronal molecular mechanisms

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dc.authoridKARABULUT, SEBAHATTIN/0000-0002-3261-4125
dc.contributor.authorCetin, Ali
dc.contributor.authorOzdemir, Ercan
dc.contributor.authorGolgeli, Asuman
dc.contributor.authorTaskiran, Ahmet Sevki
dc.contributor.authorKarabulut, Sebahattin
dc.contributor.authorErgul, Mustafa
dc.contributor.authorGumus, Erkan
dc.date.accessioned2024-10-26T18:10:52Z
dc.date.available2024-10-26T18:10:52Z
dc.date.issued2024
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractBackgroundAnxiety is an adaptive response to potentially threatening conditions. Excessive and uncontrolled anxiety responses become nonadaptive and cause anxiety disorders. To better understand the anxiety-modulating effects of Mg sulfate, behavioral test batteries in the assessment of anxiety and learning and memory functions were performed simultaneously over a time period. This study also examines the effects of Mg sulfate compared to diazepam, an anxiolytic drug with amnestic effects on anxiety-like behavior, as well as possible oxidative-nitrosative stress and hippocampal changes in male rats exposed to predator odor.MethodsYoung adult Sprague-Dawley male rats were used. The rats were assessed using a comprehensive neurobehavioral test battery consisting of novel object recognition, open field, and successive alleys tasks. Anxiety was induced by cat odor, and diazepam and Mg were used as study drugs. Of the frontal cortex and hippocampus, the state of total oxidant and antioxidant and NO levels and histological examination of hippocampal CA1, CA2, CA3, and DG regions were performed.ResultsDiazepam- and Mg-treated rats showed an improvement in anxiety-related behavior to predator odors. Furthermore, Mg treatment alleviated some of the increasing oxidative stress in the frontal cortex and hippocampus of rats, while diazepam treatment in particular enhanced hippocampal oxidant and antioxidant activity. In addition, brain NO increase induced by animal odor exposure or diazepam treatment was ameliorated by Mg administration.ConclusionsOverall, our work suggests that Mg had a partial anxiolytic effect on anxiety-like behaviors, although not as much as diazepam, and this effect varied depending on the dose. Mg treatment might counteract increased oxidative stress and elevated NO levels in the brain.
dc.description.sponsorshipCumhuriyet University Scientific Research Project, Sivas, Turkey (CUBAP) [T-807]
dc.description.sponsorshipThis work is partially funded by Cumhuriyet University Scientific Research Project, Sivas, Turkey (CUBAP, Grant Number: T-807).
dc.identifier.doi10.1080/01616412.2024.2352234
dc.identifier.endpage762
dc.identifier.issn0161-6412
dc.identifier.issn1743-1328
dc.identifier.issue8
dc.identifier.pmid38719201
dc.identifier.scopus2-s2.0-85192538055
dc.identifier.scopusqualityQ2
dc.identifier.startpage752
dc.identifier.urihttps://doi.org/10.1080/01616412.2024.2352234
dc.identifier.urihttps://hdl.handle.net/20.500.12418/30421
dc.identifier.volume46
dc.identifier.wosWOS:001216431500001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofNeurological Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAnxiety-like behavior
dc.subjectpredator odor
dc.subjectnovel object recognition
dc.subjectopen field and successive alleys
dc.subjectoxidative stress
dc.subjectnitrosative stress
dc.subjectdiazepam
dc.subjectmagnesium
dc.titleThe effect of magnesium sulfate on memory and anxiety-like behavior in a rat model: an investigation of its neuronal molecular mechanisms
dc.typeArticle

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