Synthetic (JWH-018) cannabinoid-induced immune suppression of T-lymphocytes in spleen tissue

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dc.contributor.authorMutluay, Duygu
dc.contributor.authorTenekeci, Gozde Yucel
dc.contributor.authorAmbarcioglu, Pinar
dc.contributor.authorUslu, Sema
dc.date.accessioned2024-10-26T18:09:53Z
dc.date.available2024-10-26T18:09:53Z
dc.date.issued2024
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractSynthetic cannabinoid JWH-018 is a potent cannabinoid receptor agonist that plays a role in the immune system. It is a substance whose consumption is rising globally. While numerous studies have explored the impact of cannabinoids on immunity, limited information exists regarding the immunosuppressive effects on T cells within spleen tissue. Hence, this study aims to investigate the effects of JWH-018 on CD cells in the spleen. Thirty male CD -1 mice were categorized into three groups: the sham group (G1), the ethanol group (G2), and the JWH-018 group (G3). These animals received treatments of saline, ethanol, and JWH-018 (0.3 mg/kg) respectively for 9 consecutive days, after which all groups were sacrificed on day 2. Our findings revealed a statistically significant weight loss in G3 compared to G2, whereas a weight gain was observed in G1 and G2. Except for one animal, no significant histopathological changes were detected in the control and treatment groups. However, the treatment group exhibited a notable decrease in white pulp size. Moreover, we demonstrated that JWH-018 can induce apoptosis, leading to a decrease in CD3, CD4, and CD8 expression in T cells, which may result in immunosuppression in vivo in T lymphocytes. These results collectively suggest that exposure to JWH-018 can lead to the suppression of CD3, CD4, and CD8 expression by inducing apoptosis. Consequently, the results of this study show that JWH-018 may have a potential for use as an immunosuppressant in various medical conditions, particularly in autoimmune diseases or situations requiring immune system suppression.
dc.identifier.doi10.21521/mw.6860
dc.identifier.endpage167
dc.identifier.issn0025-8628
dc.identifier.issue4
dc.identifier.scopus2-s2.0-85186679784
dc.identifier.scopusqualityQ3
dc.identifier.startpage161
dc.identifier.urihttps://doi.org/10.21521/mw.6860
dc.identifier.urihttps://hdl.handle.net/20.500.12418/30330
dc.identifier.volume80
dc.identifier.wosWOS:001175877200003
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherPolish Soc Veterinary Sciences Editorial Office
dc.relation.ispartofMedycyna Weterynaryjna-Veterinary Medicine-Science and Practice
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectJWH-018
dc.subjectimmunity
dc.subjectimmunosuppression
dc.subjectspleen
dc.subjectsynthetic cannabinoid
dc.titleSynthetic (JWH-018) cannabinoid-induced immune suppression of T-lymphocytes in spleen tissue
dc.typeArticle

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