Anticancer properties of bromelain: State-of-the-art and recent trends

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dc.authoridSharopov, Farukh/0000-0003-0378-8887
dc.authoridGulsunoglu Konuskan, Zehra/0000-0001-6497-1912
dc.authoridTynybekov, Bekzat/0009-0003-6176-2113
dc.authoridSharifi-Rad, Javad/0000-0002-7301-8151
dc.authoridCalina, Daniela/0000-0002-1523-9116
dc.contributor.authorPezzani, Raffaele
dc.contributor.authorJimenez-Garcia, Manuel
dc.contributor.authorCapo, Xavier
dc.contributor.authorSonmez Gurer, Eda
dc.contributor.authorSharopov, Farukh
dc.contributor.authorRachel, Tchokouaha Yamthe Lauve
dc.contributor.authorNtieche Woutouoba, David
dc.date.accessioned2024-10-26T18:11:43Z
dc.date.available2024-10-26T18:11:43Z
dc.date.issued2023
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractBromelain is a key enzyme found in pineapple (Ananas comosus (L.) Merr.); a proteolytic substance with multiple beneficial effects for human health such as anti-inflammatory, immunomodulatory, antioxidant and anticarcinogenic, traditionally used in many countries for its potential therapeutic value. The aim of this updated and comprehensive review focuses on the potential anticancer benefits of bromelain, analyzing the cytotoxic, apoptotic, necrotic, autophagic, immunomodulating, and anti-inflammatory effects in cancer cells and animal models. Detailed information about Bromelain and its anticancer effects at the cellular, molecular and signaling levels were collected from online databases such as PubMed/MedLine, TRIP database, GeenMedical, Scopus, Web of Science and Google Scholar. The results of the analyzed studies showed that Bromelain possesses corroborated pharmacological activities, such as anticancer, anti-edema, anti-inflammatory, anti-microbial, anti-coagulant, anti-osteoarthritis, anti-trauma pain, anti-diarrhea, wound repair. Nonetheless, bromelain clinical studies are scarce and still more research is needed to validate the scientific value of this enzyme in human cancer diseases.
dc.identifier.doi10.3389/fonc.2022.1068778
dc.identifier.issn2234-943X
dc.identifier.pmid36698404
dc.identifier.scopus2-s2.0-85146901665
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.3389/fonc.2022.1068778
dc.identifier.urihttps://hdl.handle.net/20.500.12418/30775
dc.identifier.volume12
dc.identifier.wosWOS:000922666300001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherFrontiers Media Sa
dc.relation.ispartofFrontiers in Oncology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectbromelain
dc.subjectcancer
dc.subjectchemotherapeutics
dc.subjectcytotoxicity
dc.subjectapoptosis
dc.subjectmolecular targets
dc.titleAnticancer properties of bromelain: State-of-the-art and recent trends
dc.typeReview Article

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