Anticancer and Cytotoxic Activities of Some Trigonella Species on MCF-7, L929 and HeLa Cell Lines

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dc.authoridakan, hasan/0000-0002-3033-4349
dc.authoridGumushan Aktas, Hatice/0000-0002-6650-184X
dc.authoridTAKIM, KASIM/0000-0003-4631-1982
dc.authoridDurna Dastan, Sevgi/0000-0003-4946-5602
dc.contributor.authorMojarradgandoukmolla, Shahrokh
dc.contributor.authorAkan, Hasan
dc.contributor.authorKasim, Takim
dc.contributor.authorDastan, Sevgi Durna
dc.contributor.authorAktas, Hatice Gumushan
dc.date.accessioned2024-10-26T18:09:42Z
dc.date.available2024-10-26T18:09:42Z
dc.date.issued2024
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractTrigonella filipes Boiss, Trigonella strangulata Boiss., and Trigonella uninata Banks and Sol., are three commonly used species that grow well in Iraq's northern suburbs and are frequently consumed and used in traditional medicine. The current study was planned to assess and identify the active chemicals in these plant species, as well as to analyze their anticancer and antiprofeliration effects in rats treated with alcohol and cholesterol. Plant extracts were tested for oxidative stress index (OSI), total oxidant status (TOS), and total antioxidant status (TAS). Administration of Trigonella foenum-graecum and Trigonella monantha significantly improved these changes in diseased rats. MTT cytotoxicity test was used to investigate the cytotoxic properties of Trigonella filipes, Trigonella strangulata, and Trigonella uncinata plant extracts on three distinct cell lines in varied concentrations (1-10-100-1000 g/mL) after 24 h of incubation. The results were supported that these three plant taxa have high phytochemical compounds that have physiological effects such as inhibit cell proliferation, improving the function of liver and kidney function, and antioxidants effect.
dc.description.sponsorshipHUBAK of Harran University, Sanliurfa, Turkey
dc.description.sponsorshipThe authors gratefully recognize the HUBAK of Harran University, Sanliurfa, Turkey for partially supporting this project and offering the best facility for research.
dc.identifier.doi10.1134/S1062359023603567
dc.identifier.endpage834
dc.identifier.issn1062-3590
dc.identifier.issn1608-3059
dc.identifier.issue4
dc.identifier.scopus2-s2.0-85195136116
dc.identifier.scopusqualityQ4
dc.identifier.startpage829
dc.identifier.urihttps://doi.org/10.1134/S1062359023603567
dc.identifier.urihttps://hdl.handle.net/20.500.12418/30243
dc.identifier.volume51
dc.identifier.wosWOS:001236820200003
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherPleiades Publishing Inc
dc.relation.ispartofBiology Bulletin
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectTrigonella
dc.subjectoxidative stress index
dc.subjecttotal oxidant status
dc.subjecttotal antioxidant status
dc.titleAnticancer and Cytotoxic Activities of Some Trigonella Species on MCF-7, L929 and HeLa Cell Lines
dc.typeArticle

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