Relationship between lower extremity sensation, physical activity, cognition, body awareness, and fatigue in people with multiple sclerosis: a cross-sectional study

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dc.authoridYildirim, Muhammed Seref/0000-0002-8529-986X
dc.contributor.authorEldemir, Kader
dc.contributor.authorOzkul, Cagla
dc.contributor.authorYildirim, Muhammed Seref
dc.contributor.authorEldemir, Sefa
dc.contributor.authorSaygili, Fettah
dc.contributor.authorIrkec, Ceyla
dc.contributor.authorGuclu-Gunduz, Arzu
dc.date.accessioned2025-05-04T16:47:22Z
dc.date.available2025-05-04T16:47:22Z
dc.date.issued2025
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractBackground Multiple sclerosis (MS) is a chronic autoimmune disease causing sensory and motor impairments due to central nervous system demyelination. Sensory feedback, essential for balance and gait, is often disrupted in people with MS (PwMS). However, its relationship with fatigue, physical activity, cognitive function, and body awareness remains unclear. Aim To investigate the relationship between plantar sensation, knee position sense, and clinical factors in PwMS compared to healthy controls (HC). MethodsThirty-three PwMS and 11 HC participated in this study. Foot sensations including light touch threshold, two-point discrimination, vibration duration, and knee position sense were assessed. In addition, physical activity level, cognitive function, body awareness, and fatigue were assessed as clinical factors. Results No significant differences were found between PwMS and HC in most sensory measures, except for body awareness, which was higher in HC (p:0.029). In PwMS, light touch thresholds correlated with age (r = 0.454, p = 0.008), vibration duration with walking and physical activity levels (r = 0.392-0.396, p < 0.05), two-point discrimination with EDSS score (r = 0.474, p = 0.005), knee position sense with EDSS (r = 0.385, p = 0.027) and cognitive function (r = 0.382, p = 0.028). In HC, vibration duration correlated negatively with age (r=-0.834, p:0.001), and knee position sense correlated with body mass index (r = 0.764, p:0.006) and cognitive function (r = 0.609-0.736, p < 0.05). Conclusion These findings highlight the relationship between sensory function and clinical factors in PwMS, emphasizing the importance of age, disability level, physical activity, and cognitive function in preserving the sensory functions of the lower extremity.
dc.identifier.doi10.1007/s13760-025-02768-1
dc.identifier.issn0300-9009
dc.identifier.issn2240-2993
dc.identifier.pmid40133734
dc.identifier.scopus2-s2.0-105001041869
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1007/s13760-025-02768-1
dc.identifier.urihttps://hdl.handle.net/20.500.12418/35570
dc.identifier.wosWOS:001451329000001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer Heidelberg
dc.relation.ispartofActa Neurologica Belgica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250504
dc.subjectAwareness
dc.subjectCognition
dc.subjectFatigue
dc.subjectMultiple sclerosis
dc.subjectSensation
dc.subjectWalking
dc.titleRelationship between lower extremity sensation, physical activity, cognition, body awareness, and fatigue in people with multiple sclerosis: a cross-sectional study
dc.typeArticle

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