Evaluation of the relationship of leptin, adiponectin and carnitine levels with lung function, asthma severity and BMI in children with asthma

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dc.contributor.authorBaylan, Filiz Alkan
dc.contributor.authorDeveci, Köksal
dc.contributor.authorAygüneş, Utku
dc.contributor.authorHaskoloğlu, Zehra Şule
dc.date.accessioned2024-10-26T17:51:16Z
dc.date.available2024-10-26T17:51:16Z
dc.date.issued2021
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractPurpose: The aim of this study is to evaluate the relationship between serum levels of leptin, adiponectin and carnitine with lung function, disease severity and BMI (Body Mass Index) in children with asthma. Materials and methods: 97 Pediatric patients with not in acute attack period bronchial asthma and 40 healthy control subjects were included in the study. Pulmonary function tests were done to all asthma patients with a spirometer. Children with asthma were divided into 3 groups according to GINA criteria, mild intermittent, mild persistent, and moderate persistent, with using symptoms and spirometric parameters according to the severity of airway obstruction. Leptin, total carnitine and adiponectin analyzes were performed from venous blood by ELISA method. Results: Patient group serum leptin values were found to be significantly higher than the control group serum leptin values (p=0.001). Patient group serum total carnitine values were found to be significantly lower than the control group (p=0.001). Moderate persistent group adiponectin and total carnitine values were found to be significantly lower than mild intermittent group (p<0.05). A weak negative correlation was found between leptin and total carnitine, eosinophil, BMI values. A weak negative correlation was found between total carnitine and eosinophil, BMI values. A moderate negative correlation was found between age and leptin, adiponectin, total carnitine values. Conclusions: It suggested that leptin levels increased, adiponectin and total carnitine levels decreased in children with asthma and at the same time the decrease in adiponectin and total carnitine levels may be associated with disease severity. © 2021, Pamukkale University. All rights reserved.
dc.description.sponsorshipSivas Cumhuriyet Üniversitesi, (20.05.2011 / 164)
dc.identifier.doi10.31362/patd.791578
dc.identifier.endpage321
dc.identifier.issn1309-9833
dc.identifier.issue2
dc.identifier.scopus2-s2.0-85160950206
dc.identifier.scopusqualityN/A
dc.identifier.startpage312
dc.identifier.trdizinid422902
dc.identifier.urihttps://doi.org/10.31362/patd.791578
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/422902
dc.identifier.urihttps://hdl.handle.net/20.500.12418/26132
dc.identifier.volume14
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherPamukkale University
dc.relation.ispartofPamukkale Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectadiponectine; Asthma; carnitine; leptine
dc.titleEvaluation of the relationship of leptin, adiponectin and carnitine levels with lung function, asthma severity and BMI in children with asthma
dc.title.alternativeAstımlı çocuklarda leptin, adiponektin ve karnitin düzeylerinin akciğer fonksiyonları, astım şiddeti ve BMI ile ilişkisinin değerlendirilmesi
dc.typeArticle

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