Hydrophilic vs. amphiphilic anionic Zn(II) phthalocyanines for photodynamic therapy

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dc.authoridMakhseed, Ethar/0009-0006-4272-9360
dc.contributor.authorAl-Hamdan, Nouf S.
dc.contributor.authorMakhseed, Ethar S.
dc.contributor.authorHusain, Ali
dc.contributor.authorBagda, Efkan
dc.contributor.authorBagda, Esra
dc.contributor.authorDuman, Didem
dc.contributor.authorAyhan, Ebubekir
dc.date.accessioned2025-05-04T16:47:09Z
dc.date.available2025-05-04T16:47:09Z
dc.date.issued2025
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractTwo sets of water-soluble zinc (II) phthalocyanines (Zn[II]Pcs) were synthesized and examined for use as photosensitizers in photodynamic therapy. These Zn(II)Pcs contained numerous negatively charged electronwithdrawing carboxylic acid substituents in a rigid arrangement at peripheral positions, subsequently converted into sodium salts. Additionally, the impact of the number and distribution of charged groups on the planar hydrophobic core was examined to assess their influence on the photophysical properties and self-aggregation behavior of the Pcs in an aqueous media. The photophysical findings indicate that the amphiphilic macrocycles (2A, 3A, and 4A) produce more singlet oxygen than the hydrophilic ones (2H, 3H, and 4H) in DMF. The photodynamic activity of sodium salts of Zn(II)Pcs bearing anionic substituents (compounds 4A and 4H) was evaluated in vitro against oral squamous cell carcinoma (SCC-9) and mouse fibroblast (L-929) cell lines to help elucidate the cell death mechanism. The results confirmed that 4A exhibits high selectivity and efficiency in causing phototoxicity, with an IC50 value of around 3.8 mu M. This work provides new insights into the advanced development of dual-directional ZnPc-based photodynamic therapy agents for treating oral squamous cell cancer.
dc.description.sponsorshipKuwait Foundation for the Advancement of Science- KFAS [PN18-12SC-01]; Kuwait University Research administration; RSP unit general facilities of the Faculty of Science GFS [GS 01/01, GS 03/01, GS 01/03, GS 01/05, GS 02/13, GS 03/08, GS 02/01, GS 01/08]; Chemistry Department at Kuwait University
dc.description.sponsorshipThis work was supported by the Kuwait Foundation for the Advancement of Science- KFAS (grant no. PN18-12SC-01) and the Kuwait University Research administration; RSP unit general facilities of the Faculty of Science GFS (GS 01/01, GS 03/01, GS 01/03, GS 01/05, GS 02/13, GS 03/08, GS 02/01, GS 01/08) . The Chemistry Department at Kuwait University is highly acknowledged for using the MALDI-TOF mass spectrometer.
dc.identifier.doi10.1016/j.kjs.2025.100415
dc.identifier.issn2307-4108
dc.identifier.issn2307-4116
dc.identifier.issue3
dc.identifier.scopus2-s2.0-105001369877
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.kjs.2025.100415
dc.identifier.urihttps://hdl.handle.net/20.500.12418/35499
dc.identifier.volume52
dc.identifier.wosWOS:001458184500001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofKuwait Journal of Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250504
dc.subjectPhthalocyanines
dc.subjectDual-directionality
dc.subjectZinc (II) phthalocyanine
dc.subjectPhotodynamic therapy
dc.subjectOral cancer
dc.titleHydrophilic vs. amphiphilic anionic Zn(II) phthalocyanines for photodynamic therapy
dc.typeArticle

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