Synthesis of New Cinnamoyl-Amino Acid Conjugates and in Vitro Cytotoxicity and Genotoxicity Studies

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dc.authoridTekin, Suat/0000-0002-2757-1802
dc.authoridKORAN, Kenan/0000-0002-2218-7211
dc.authoridCaliskan, Eray/0000-0003-2399-4100
dc.authoridGorgulu, Ahmet Orhan/0000-0003-0632-4834
dc.authoridAltay Ozturk, Dilara/0000-0003-1126-7416
dc.contributor.authorCaliskan, Eray
dc.contributor.authorOzturk, Dilara Altay
dc.contributor.authorKoran, Kenan
dc.contributor.authorTekin, Suat
dc.contributor.authorSandal, Suleyman
dc.contributor.authorErkan, Sultan
dc.contributor.authorGorgulu, Ahmet Orhan
dc.date.accessioned2024-10-26T18:11:17Z
dc.date.available2024-10-26T18:11:17Z
dc.date.issued2022
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractAmino acid conjugates are described by the reaction of amino acids with bioactive organic groups such as vitamins, hormones, flavonoids, steroids, and sugars. In this study, 12 new conjugates were synthesized by reaction of cinnamic acid derivatives with various amino acids. Cytotoxic studies against four different human cancer cells (MCF7, PC-3, Caco-2, and A2780) were carried out by MTT assay method at five different concentrations. The structure-activity relationships based on the cell viability rates were evaluated. To compare the anticancer activities of the compounds using computational chemistry methods, they were docked against A2780 human ovarian cancer, Michigan Cancer Foundation-7 (MCF7), human prostate cancer (PC-3) and human colon epidermal adenocarcinoma (Caco-2) cell lines and compared with the standard 5-Fluorouracil. The results indicate that the efficacy of cinnamic acid derivatives increases with the presence of amino acids. Comet assay was conducted to understand whether the cell deaths occur through DNA damage mechanism and the results exhibit that the changes in the specified parameters were statistically significant (p<0.05). Our study demonstrated that the compounds cause cell death through the formation of DNA damage mechanism.
dc.description.sponsorshipInonu University Scientific Research Unit [TSG-2020-2183]; Bingol University Scientific Research Projects Coordination Unit [FEF.2018.00.003]
dc.description.sponsorshipBiological studies of this work were supported by Inonu University Scientific Research Unit (Project No: TSG-2020-2183) and synthesis parts of this work were produced from Eray Calkan's Ph.D. thesis which was supported by Bingol University Scientific Research Projects Coordination Unit (Project No. FEF.2018.00.003).
dc.identifier.doi10.1002/cbdv.202200426
dc.identifier.issn1612-1872
dc.identifier.issn1612-1880
dc.identifier.issue8
dc.identifier.pmid35864058
dc.identifier.scopus2-s2.0-85135537884
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1002/cbdv.202200426
dc.identifier.urihttps://hdl.handle.net/20.500.12418/30584
dc.identifier.volume19
dc.identifier.wosWOS:000837319700001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley-V C H Verlag Gmbh
dc.relation.ispartofChemistry & Biodiversity
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectamino acid
dc.subjectcinnamic acid
dc.subjectcytotoxicity
dc.subjectDNA damage
dc.subjectsynthesis
dc.titleSynthesis of New Cinnamoyl-Amino Acid Conjugates and in Vitro Cytotoxicity and Genotoxicity Studies
dc.typeArticle

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