Evaluation of the Effects of Locally Applied Resveratrol and Cigarette Smoking on Bone Healing

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dc.authoridCina, Muge/0000-0003-2005-3153
dc.contributor.authorIskender, Muhsin Firat
dc.contributor.authorCina, Muge
dc.contributor.authorCamli, Sevket Tolga
dc.contributor.authorCiris, Ibrahim Metin
dc.contributor.authorYuceer, Ramazan Oguz
dc.date.accessioned2024-10-26T18:09:15Z
dc.date.available2024-10-26T18:09:15Z
dc.date.issued2024
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractBackground: Bone healing is a complex process controlled by various mechanisms. It is known that cigarette smoking (CS) negatively affects bone healing by disrupting many of these mechanisms. In an effort to find ways to eliminate these negative effects caused by CS, studies have been conducted on various vitamins, antioxidants, and medications. Since high doses and repeated injections are required to increase the therapeutic effect of conventional drug applications, controlled drug delivery systems have been developed to avoid such problems. This study aimed to investigate the effects of resveratrol (RES), which has been made into a controlled drug delivery system, on bone healing in rats that were experimentally exposed to cigarette smoke to create a chronic smoking model. Methods: After establishing a chronic CS model by exposing the subjects to cigarette smoke of six cigarettes/day for four weeks, monocortical critical size defects of 3 mm (SD +/- 0.02 mm) in diameter were created in the femur using a trephine bur. During the operation, the defects in RES groups were filled locally with a gel-formed solution of RES (50 mu M) and Pluronic F-127 (14 mu L). CS exposure was continued during the bone healing period after surgery. All groups were sacrificed one month after the operation, and femur samples were taken. Results: The obtained samples were examined by histomorphometric and immunohistochemical techniques; osteoblast count, new bone area, macroscopic filling score, vascularization, and proliferation were evaluated. Conclusion: The results of this study indicate that CS negatively affects bone healing and that local application of RES reduces this effect.
dc.description.sponsorshipDepartment of Scientific Research Projects, Suleyman Demirel University [TDH-2021-8455]
dc.description.sponsorshipThe present study was funded by the Department of Scientific Research Projects, Suleyman Demirel University (Grant/Award Number: TDH-2021-8455).
dc.identifier.doi10.3390/app14156411
dc.identifier.issn2076-3417
dc.identifier.issue15
dc.identifier.scopus2-s2.0-85200735533
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.3390/app14156411
dc.identifier.urihttps://hdl.handle.net/20.500.12418/30027
dc.identifier.volume14
dc.identifier.wosWOS:001286915900001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofApplied Sciences-Basel
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectresveratrol
dc.subjectcontrolled drug delivery systems
dc.subjectcigarette smoking
dc.subjectbone healing
dc.titleEvaluation of the Effects of Locally Applied Resveratrol and Cigarette Smoking on Bone Healing
dc.typeArticle

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