Preparation and characterization of chitosan nanoparticles with extracts of Rheum ribes, evaluation of biological activities of extracts and extract loaded nanoparticles

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dc.contributor.authorDoğan, Murat
dc.contributor.authorKoçyiğit, Ümit Muhammet
dc.contributor.authorTaşkın, Duygu
dc.contributor.authorYılmaz, Beyza Nur
dc.contributor.authorTaşkın, Turgut
dc.date.accessioned2025-05-04T16:41:56Z
dc.date.available2025-05-04T16:41:56Z
dc.date.issued2024
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractThe biological activities of different parts of the Rheum ribes plant were evaluated comparatively. Extracts showing strong biological activity were identified and it was determined which of the extract-loaded nanoparticles showed stronger activity. Cytotoxic activity of R. ribes extracts was calculated on glial (C6) and fibroblast (NIH 3T3) cells using XTT assay. Spectrophotometry was used to evaluate the impact of these compounds on the enzyme activities of human carbonic anhydrase I and II (hCA I and hCA II). The findings showed that chitosan NPs with extracts loaded on them have a lower IC50 value and more cytotoxic activity in C6 cells than chitosan NPs with only extracts. R. ribes young shoots ultrasonic methanol extract (RYU) was shown to have the strongest antiproliferative efficacy against C6 cells. Results showed that RYU and ultrasonic methanol extract of R. ribes radix (RRU) were determined as the best carbonic anhydrase inhibitors. According to results of particle size, encapsulation efficiency, and release studies of chitosan NPs, it has been observed that they are suitable for application. At a concentration of 10 µg/mL, it was found that none of the R. ribes extracts exhibited cytotoxic action toward the NIH 3T3 cell line. According to results of particle size, encapsulation efficiency, and release studies of chitosan NPs, it has been observed that they are suitable for application. It was observed that none of the extracts of R. ribes at a concentration of 10 µg/mL showed cytotoxic activity in the NIH 3T3 cell line. © The Author(s) 2024.
dc.description.sponsorshipSivas Cumhuriyet Üniversitesi
dc.description.sponsorshipMarmara Üniversitesi
dc.identifier.doi10.21448/ijsm.1425978
dc.identifier.endpage764
dc.identifier.issn2148-6905
dc.identifier.issue4
dc.identifier.scopus2-s2.0-85208130595
dc.identifier.scopusqualityQ3
dc.identifier.startpage751
dc.identifier.trdizinid1283630
dc.identifier.urihttps://doi.org/10.21448/ijsm.1425978
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1283630
dc.identifier.urihttps://hdl.handle.net/20.500.12418/34990
dc.identifier.volume11
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherPamukkale University
dc.relation.ispartofInternational Journal of Secondary Metabolite
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_Scopus_20250504
dc.subjectBioactivity
dc.subjectCharacterization of nanoparticles
dc.subjectChitosan nanoparticles
dc.subjectCytotoxicity
dc.subjectRheum ribes
dc.titlePreparation and characterization of chitosan nanoparticles with extracts of Rheum ribes, evaluation of biological activities of extracts and extract loaded nanoparticles
dc.typeArticle

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