Changes in spontaneous contractions of rat ileum by aflatoxin in vitro

Basit Öğe Kaydı
dc.contributor.authorGursoy, Nevcihan
dc.contributor.authorSarac, Bulent
dc.contributor.authorDurmus, Nedim
dc.contributor.authorParlak, Ahmet
dc.contributor.authorYildirim, Sahin
dc.contributor.authorKaya, Tijen
dc.contributor.authorBagcivan, Ihsan
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T10:15:14Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T10:15:14Z
dc.date.issued2008
dc.department[Gursoy, Nevcihan] Cumhuriyet Univ, Fac Engn, Dept Food Engn, TR-58140 Sivas, Turkey -- [Sarac, Bulent -- Durmus, Nedim -- Parlak, Ahmet -- Yildirim, Sahin -- Kaya, Tijen -- Bagcivan, Ihsan] Cumhuriyet Univ, Sch Med, Dept Pharmacol, TR-58140 Sivas, Turkeyen_US
dc.description.abstractAflatoxins are a group of mycotoxins produced by toxigenic strains of Aspergillus flavus, Aspergillus parasiticus and Aspergillus nomius as secondary metabolites. Most of the studies on the aflatoxins have focused mainly on their chronic toxic effects but aflatoxins have also a lot of acute effects on the respiratory, cardiovascular and gastrointestinal systems. In this study the acute gastrointestinal effects of the aflatoxins on rat isolated ileum and the possible mechanisms underlying contractile responses to them were investigated. Aflatoxin increased both of the amplitude and the frequency of spontaneous contractions in a dose-dependent manner. Pretreatment with a cholinergic system inhibitor, atropine sulfate (23.6 nM), a specific sodium-channel blocker, tetrodotoxin (0.3 mu M) and an inhibitor of ACh release from terminal motor neurons, morphine (0.3 mu M) decreased both of aflatoxin induced spontaneous contractions' amplitude and frequency, in contrast a nicotinic ganglionic blocker, hexamethonium chloride (55 mu M) did not change the aflatoxin effect. But the decrease of amplitude was more than the frequency in the presence of these antagonists. In conclusion, these findings of aflatoxin on isolated rat ileum may explain their acute gastrointestinal effects in humans and animals. (C) 2008 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.fct.2008.02.005en_US
dc.identifier.endpage2127en_US
dc.identifier.issn0278-6915
dc.identifier.issue6en_US
dc.identifier.pmid18353519en_US
dc.identifier.scopus2-s2.0-42749086439en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpage2124en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.fct.2008.02.005
dc.identifier.urihttps://hdl.handle.net/20.500.12418/10367
dc.identifier.volume46en_US
dc.identifier.wosWOS:000256512200030en_US
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPERGAMON-ELSEVIER SCIENCE LTDen_US
dc.relation.ispartofFOOD AND CHEMICAL TOXICOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectaflatoxinen_US
dc.subjectamplitudeen_US
dc.subjectfrequencyen_US
dc.subjectileumen_US
dc.titleChanges in spontaneous contractions of rat ileum by aflatoxin in vitroen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksyonu
Scopus İndeksli Yayınlar Koleksiyonu