Evaluation of structural, spectral characterization and in vitro cytotoxic activity studies of some polycyclic aromatic compounds

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dc.authoridSahin-Bolukbasi, Serap/0000-0003-1057-2558
dc.authoridRezaeivala, Majid/0000-0002-4516-4055
dc.contributor.authorRezaeivala, Majid
dc.contributor.authorSayin, Koray
dc.contributor.authorSahin-Bolukbasi, Serap
dc.contributor.authorTandogan, Derya
dc.contributor.authorKose, Muhammet
dc.contributor.authorKose, Aysegul
dc.date.accessioned2024-10-26T18:07:19Z
dc.date.available2024-10-26T18:07:19Z
dc.date.issued2020
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractThe present study aims to introduce three known and three new stable polycyclic aromatic compounds synthesized. With MALDI-Mass, H-1 and C-13 NMR spectroscopy, all new compounds were characterized. In the DMF solution were carried out the electrochemical and photophysical properties of the polyaromatic compounds. The compounds are highly fluorescent showing green-red emission when excited at one single wavelength. For the compound 3, it was shown that the highest Stokes Shift (191 nm) appeared which may be due to the excited state energy transfer. The compounds also indicated the blue-orange region of the electromagnetic spectrum strong emission bands. Additionally, compounds 1, 3, 4, and 5 were investigated for their in vitro cytotoxic activities against PC-3 prostate cancer cells, L-929 non-cancerous cells, and MDA-MB-231 breast cancer for 24 h, 48 h and 72 h. The results obtained from the experiment demonstrated that compounds had different cytotoxic activity against cell lines. Compound 3 was indicated to be inactive against L-929 cells and MDA-MB-231 cancer cells, whereas compounds 1, 4 and 5 indicated a dose and time-dependent cytotoxic activity against PC-3, MDA-MB-231, and L-929 cell lines. It was found that the most sensitive cells to compound 5 were MDA-MB-231 human breast cancer cells. Additionally, it became clear that compounds 1 and 3 had significant selectivity for human PC-3 prostate cancer cells, and compounds 1, 4 and 5 had considerable selectivity for human MDA-MB-231 breast cancer cells. Also, the quantum chemical examinations of six organic compounds were conducted at the B3LYP/6-31G level in the gas phase and water. According to calculated results, compound 5 was found to be the best candidate for NLO applications. (C) 2020 The Author(s). Published by Elsevier B.V. on behalf of King Saud University.
dc.description.sponsorshipDepartment of Chemical Engineering Hamedan University of Technology, Ministry of Science, Research and Technology of Iran; Department of Chemistry, Northwestern University
dc.description.sponsorshipWe are grateful to the Department of Chemical Engineering Hamedan University of Technology, Ministry of Science, Research and Technology of Iran, for financial support and to the Prof. Sir. J. Fraser Stoddart at Department of Chemistry, Northwestern University for a Visiting Fellowship to M. R in 2016. This research is made possible by TUBITAK ULAKBIM, High Performance and Grid Computing Center (TR-Grid e-Infrastructure). Cytotoxic activity studies were done at Sivas Cumhuriyet University Advanced Technology Application and Research Center (SCUTAM).
dc.identifier.doi10.1016/j.arabjc.2020.03.021
dc.identifier.endpage5604
dc.identifier.issn1878-5352
dc.identifier.issn1878-5379
dc.identifier.issue6
dc.identifier.scopus2-s2.0-85083722505
dc.identifier.scopusqualityQ1
dc.identifier.startpage5593
dc.identifier.urihttps://doi.org/10.1016/j.arabjc.2020.03.021
dc.identifier.urihttps://hdl.handle.net/20.500.12418/29448
dc.identifier.volume13
dc.identifier.wosWOS:000566223000004
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofArabian Journal of Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCytotoxic activity
dc.subjectPolycyclic aromatic compound
dc.subjectPhotoluminescence
dc.subjectTheoretical Studies
dc.titleEvaluation of structural, spectral characterization and in vitro cytotoxic activity studies of some polycyclic aromatic compounds
dc.typeArticle

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