Photodynamic activity of cationic ball-type zinc phthalocyanine in cell culture experiments with MCF-7 and MG63 cancer cells

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dc.authoridErden, Fuat/0000-0002-8261-4844
dc.contributor.authorSoylu, Sinan
dc.contributor.authorBagda, Efkan
dc.contributor.authorAltun, Ahmet
dc.contributor.authorBagda, Esra
dc.contributor.authorKurt, Atilla
dc.contributor.authorErden, Fuat
dc.contributor.authorYabas, Ebru
dc.date.accessioned2025-05-04T16:46:04Z
dc.date.available2025-05-04T16:46:04Z
dc.date.issued2024
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractEffective binding of cationic ball-type zinc phthalocyanine (BT-Pc) to G-quadruplex (G4) DNA molecules has already been demonstrated previously. This motivated us to investigate the PDT performance of BT-Pc in cell culture studies. Accordingly, the present work involves the application of BT-Pc to breast (MCF-7) and osteosarcoma (MG63) cancer cells, and also to healthy fibroblast cells (L929). Cell lines (CL) were irradiated at 640 nm wavelength, and the photodynamic activity was evaluated. The results show that cytotoxicity was significantly stronger in MCF-7 cells than in both L929 and MG63 cells (p < 0.05) in the absence of IPL irradiation. Also, we report that the application of l IPL provided significant photodynamic activity in MCF-7 and MG63 cells (p < 0.05). These results further suggest that BT-Pc might become a promising photosensitizer for future clinical trials.
dc.identifier.doi10.1142/S1088424624500494
dc.identifier.endpage502
dc.identifier.issn1088-4246
dc.identifier.issn1099-1409
dc.identifier.issue8
dc.identifier.scopus2-s2.0-85206623998
dc.identifier.scopusqualityQ3
dc.identifier.startpage497
dc.identifier.urihttps://doi.org/10.1142/S1088424624500494
dc.identifier.urihttps://hdl.handle.net/20.500.12418/35334
dc.identifier.volume28
dc.identifier.wosWOS:001330190200005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWorld Scientific Publ Co Pte Ltd
dc.relation.ispartofJournal of Porphyrins and Phthalocyanines
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250504
dc.subjectball-type phthalocyanine
dc.subjectphotodynamic therapy
dc.subjectMCF-7
dc.subjectMG63
dc.subjectL929
dc.titlePhotodynamic activity of cationic ball-type zinc phthalocyanine in cell culture experiments with MCF-7 and MG63 cancer cells
dc.typeArticle

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