Antiangiogenic activities of bemiparin sodium, enoxaparin sodium, nadroparin calcium and tinzaparin sodium

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dc.authoridKarahan, Oguz -- 0000-0003-0044-9476; Cetin, Ali -- 0000-0002-5767-7894; Altun, Ahmet -- 0000-0003-2056-8683en_US
dc.contributor.authorDogan, Omer Tamer
dc.contributor.authorPolat, Zubeyde Akin
dc.contributor.authorKarahan, Oguz
dc.contributor.authorEpozturk, Kursat
dc.contributor.authorAltun, Ahmet
dc.contributor.authorAkkurt, Ibrahim
dc.contributor.authorCetin, Ali
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T10:05:06Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T10:05:06Z
dc.date.issued2011
dc.department[Dogan, Omer Tamer -- Epozturk, Kursat -- Akkurt, Ibrahim] Cumhuriyet Univ, Dept Chest Dis, Sch Med, Sivas, Turkey -- [Polat, Zubeyde Akin] Cumhuriyet Univ, CUTFAM Res Ctr, Sch Med, Sivas, Turkey -- [Karahan, Oguz] Cumhuriyet Univ, Dept Cardiovasc Surg, Sch Med, Sivas, Turkey -- [Altun, Ahmet] Cumhuriyet Univ, Dept Pharmacol, Sch Med, Sivas, Turkey -- [Cetin, Ali] Cumhuriyet Univ, Dept Obstet & Gynecol, Sch Med, Sivas, Turkeyen_US
dc.description.abstractIntroduction: The low-molecular-weight heparins have been demonstrated to have antiangiogenic effects in various assays. We aimed to demonstrate and compare the antiangiogenic effects of four types of commercially available low-molecular weight heparins in the chick embryo chorioallantoic membrane model. Materials and methods: The antiangiogenic efficacies of bemiparin, enoxaparin, nadroparin, and tinzaparin were examined in vivo in the chick chorioallantoic membrane model. Drug solutions are prepared in three different concentrations (100 IU, 10 IU, or 1 IU/10 mu l). For each set of experiment twenty fertilized eggs were used. The decrease of vessel formation is examined and scored according to previous literature. Results: Bemiparin, enoxaparin, nadroparin, and tinzaparin sodium all have antiangiogenic effects on chick chorioallantoic membrane at the concentration of 100 IU/10 mu l. This effect was also observed in 10 IU/10 mu l concentrations of nadroparin and tinzaparin. Conclusions: The low molecular weight heparins studied have obvious antiangiogenic effects. There may be a difference in the potency of the drugs that could have a significant implication for further clinical research. (C) 2011 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.thromres.2011.05.005en_US
dc.identifier.endpageE32en_US
dc.identifier.issn0049-3848
dc.identifier.issue4en_US
dc.identifier.pmid21605890en_US
dc.identifier.scopus2-s2.0-80054933594en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpageE29en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.thromres.2011.05.005
dc.identifier.urihttps://hdl.handle.net/20.500.12418/9456
dc.identifier.volume128en_US
dc.identifier.wosWOS:000295212200006en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPERGAMON-ELSEVIER SCIENCE LTDen_US
dc.relation.ispartofTHROMBOSIS RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAngiogenesisen_US
dc.subjectChick chorioallantoic membrane modelen_US
dc.subjectLow-molecular-weight heparinsen_US
dc.titleAntiangiogenic activities of bemiparin sodium, enoxaparin sodium, nadroparin calcium and tinzaparin sodiumen_US
dc.typeArticleen_US

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