Investigating the Effect of Hypericum Perforatum L. on Hearing in Rats: An Experimental Study

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dc.contributor.authorAltuntas, Emine Elif
dc.contributor.authorBora, Adem
dc.contributor.authorDurmus, Kasim
dc.contributor.authorKale, Hayati
dc.contributor.authorKutluhan, Ahmet
dc.date.accessioned2024-10-26T18:09:13Z
dc.date.available2024-10-26T18:09:13Z
dc.date.issued2020
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractObjectives: Hypericum perforatum L. (HP) is among the oldest used and most comprehensively studied medicinal herbs. Anti-inflammatory activities of different Hypericum extracts on external auditory canal and also in the prevention of tympanic membrane perforation and myringosclerosis were investigated experimentally in the animal model. This study was to investigate whether or not intratympanic injection of H. perforatum L. in the middle ear of the rats causes ototoxicity, via auditory brainstem response (ABR). Materials and Methods: Rats were assigned to three groups as Group C, S, and D. Excessive external auditory canal edema developed in the rats in Group D as of the 5th day and Group D was excluded from the study by considering that ABR records could be affected. Results: A statistically significant difference was observed mean latency values of the wave V and III at the baseline and on the 7th day in Group S (P < 0.05). A significant shortening was calculated in the interpeak mean latency values of the waves III-V at the baseline and on the 7th day in Group S (P < 0.05). A statistically significant difference was observed between the baseline III-V wave interpeak mean latency values in the between-group evaluation on the 7th day (P < 0.05). A statistically significant difference was detected in the mean values of the wave V/Va amplitude ratios at the baseline and on the 7th day in Group S (P < 0.05).In the between-group evaluation, a statistically significant difference was found in the mean values of the wave V/Va amplitude ratios on the 7th day (P < 0.05). Conclusion: The results of the study conducted in accordance with the hypothesis point out that the intratympanic injection of H. perforatum L. may have an ototoxic effect.
dc.identifier.doi10.4103/indianjotol.INDIANJOTOL_193_20
dc.identifier.endpage239
dc.identifier.issn0971-7749
dc.identifier.issn2249-9520
dc.identifier.issue4
dc.identifier.scopus2-s2.0-85105415411
dc.identifier.scopusqualityQ4
dc.identifier.startpage232
dc.identifier.urihttps://doi.org/10.4103/indianjotol.INDIANJOTOL_193_20
dc.identifier.urihttps://hdl.handle.net/20.500.12418/29995
dc.identifier.volume26
dc.identifier.wosWOS:000645937000007
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWolters Kluwer Medknow Publications
dc.relation.ispartofIndian Journal of Otology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAuditory brainstem response
dc.subjectherbal medicine
dc.subjectHypericum perforatum L
dc.subjectototoxicity
dc.subjectrat
dc.titleInvestigating the Effect of Hypericum Perforatum L. on Hearing in Rats: An Experimental Study
dc.typeArticle

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