Effects of alpha 2-adrenoceptor agonists dexmedetomidine and guanfacine on morphine analgesia and tolerance in rats

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dc.authoridAltun, Ahmet -- 0000-0003-2056-8683en_US
dc.contributor.authorGursoy, Sinan
dc.contributor.authorOzdemir, Ercan
dc.contributor.authorBagcivan, Ihsan
dc.contributor.authorAltun, Ahmet
dc.contributor.authorDurmus, Nedim
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T10:04:57Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T10:04:57Z
dc.date.issued2011
dc.department[Ozdemir, Ercan] Cumhuriyet Univ, Sch Med, Dept Physiol, TR-58140 Sivas, Turkey -- [Bagcivan, Ihsan -- Altun, Ahmet -- Durmus, Nedim] Cumhuriyet Univ, Sch Med, Dept Pharmacol, TR-58140 Sivas, Turkeyen_US
dc.description.abstractBackground. Alpha 2 (alpha(2))-adrenoceptor agonists may be useful for their potential to increase or prolong opioid analgesia while attenuating the development of opioid tolerance. The purpose of this study was to investigate the effects of dexmedetomidine and guanfacine (alpha(2)-adrenoceptor agonists) on morphine analgesia and tolerance in rats. Methods. Adult male Wistar albino rats weighing 195-205 g were used. To constitute morphine tolerance, animals received morphine (50 mg/kg) once daily for 3 days. After the last dose of morphine had been injected on day 4, morphine tolerance was evaluated by analgesia tests. The analgesic effects of dexmedetomidine (20 mg/kg), guanfacine (0.5 mg/kg), MK-467 (0.25 mg/kg), and morphine were estimated at 30-min intervals (0, 30, 60, 90, and 120 min) by tail-flick and hot-plate analgesia tests. Results. Our findings indicate that dexmedetomidine and guanfacine attenuated the expression of morphine tolerance. In addition, administration of dexmedetomidine with morphine increased morphine analgesia. On the contrary, data suggested that MK-467 (an alpha(2)-adrenoceptor antagonist) decreased morphine analgesia and increased morphine tolerance in analgesia tests. Conclusion. In conclusion, we observed that co-injection of dexmedetomidine or guanfacine with morphine attenuated the expression of tolerance to the analgesic effect of morphine and that dexmedetomidine enhanced the morphine analgesia.en_US
dc.description.sponsorshipCumhuriyet University, CUBAP, Sivas, Turkey [T-329]en_US
dc.description.sponsorshipThis study was supported by Cumhuriyet University Scientific Research Project (T-329, CUBAP, Sivas, Turkey).en_US
dc.identifier.doi10.3109/03009734.2011.597889en_US
dc.identifier.endpage246en_US
dc.identifier.issn0300-9734
dc.identifier.issn2000-1967
dc.identifier.issue4en_US
dc.identifier.pmid21919812en_US
dc.identifier.scopus2-s2.0-80855148082en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage238en_US
dc.identifier.urihttps://dx.doi.org/10.3109/03009734.2011.597889
dc.identifier.urihttps://hdl.handle.net/20.500.12418/9427
dc.identifier.volume116en_US
dc.identifier.wosWOS:000296794100003en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.relation.ispartofUPSALA JOURNAL OF MEDICAL SCIENCESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDexmedetomidineen_US
dc.subjectguanfacineen_US
dc.subjectmorphineen_US
dc.subjectalpha(2)-receptor agonisten_US
dc.subjecttoleranceen_US
dc.titleEffects of alpha 2-adrenoceptor agonists dexmedetomidine and guanfacine on morphine analgesia and tolerance in ratsen_US
dc.typeArticleen_US

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