Preparation of sulfatide mimicking oleic acid sulfated chitosan as a potential inhibitor for metastasis

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dc.authoridAkkaya, Birnur AKKAYA/0000-0001-9139-1884
dc.contributor.authorKocabay, Samet
dc.contributor.authorAkkaya, Birnur
dc.date.accessioned2024-10-26T18:05:19Z
dc.date.available2024-10-26T18:05:19Z
dc.date.issued2020
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractSulfatide is associated with numerous health problems, affecting different parts of the human body, including the metastasis; however, the underlying mechanisms are yet to be fully elucidated. Sulfatide has been used to potential inhibitor for tumor cell metastasis. In the present study we synthesized oleic acid sulfated chitosan (OlcShCs). It shows structural similarity to sulfatide because of its functional groups (sulfate and fatty acyl chains). Chitosan has smart properties such as biocompatibility, biodegradability and non-toxicity. We have prepared oleic acid sulfated chitosan (OlcShCs) by chitosan modification to mimic sulfatide. Its structure was characterized by FT-IR, H-NMR, and thermogravimetric analysis. After characterization studies its antimicrobial, antifungal and cytotoxic properties were investigated. Oleic acid sulfated chitosan (OlcShCs) was tested for its anti-cancer potential against human cancer cell lines (HeLa (ATCC (R) CCL-2 (TM))) for 24 h, 48 h and 72 h using the MIT assays. This new material which is soluble at physiological conditions, is a potential candidate for further metastasis inhibition investigations. (C) 2019 Elsevier B.V. All rights reserved.
dc.description.sponsorshipCumhuriyet University Scientific Research Project (CUBAP) [F-575]
dc.description.sponsorshipThis study was supported by Cumhuriyet University Scientific Research Project (CUBAP) (Project number:F-575).
dc.identifier.doi10.1016/j.ijbiomac.2019.10.119
dc.identifier.endpage798
dc.identifier.issn0141-8130
dc.identifier.issn1879-0003
dc.identifier.pmid31739035
dc.identifier.scopus2-s2.0-85075883539
dc.identifier.scopusqualityQ1
dc.identifier.startpage792
dc.identifier.urihttps://doi.org/10.1016/j.ijbiomac.2019.10.119
dc.identifier.urihttps://hdl.handle.net/20.500.12418/28935
dc.identifier.volume147
dc.identifier.wosWOS:000525864700081
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofInternational Journal of Biological Macromolecules
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectChitosan
dc.subjectSulfatide
dc.subjectAnti-microbial
dc.subjectAnti-fungal
dc.subjectCytotoxic
dc.subjectMetastasis
dc.titlePreparation of sulfatide mimicking oleic acid sulfated chitosan as a potential inhibitor for metastasis
dc.typeArticle

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