Circular RNAs serve as miRNA sponges in breast cancer

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dc.authoridAliyazicioglu, Yuksel/0000-0001-9474-4307
dc.authoridhepokur, ceylan/0000-0001-6397-1291
dc.authoridEnguita, Francisco J./0000-0002-8072-8557
dc.contributor.authorMisir, Sema
dc.contributor.authorHepokur, Ceylan
dc.contributor.authorAliyazicioglu, Yuksel
dc.contributor.authorEnguita, Francisco J.
dc.date.accessioned2024-10-26T18:09:38Z
dc.date.available2024-10-26T18:09:38Z
dc.date.issued2020
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractCircular RNAs are a large group of non-coding RNAs with a closed-loop structure. circRNAs play significant roles in many biological processes as miRNA sponges, regulators for gene transcription, combining with RNA-binding proteins and translation of protein. Nowadays, circRNAs have become a research hotspot in the field of cancer and molecular biology. Accumulating evidences have indicated that circRNAs participate in the initiation and development of various cancers such as breast cancer. Breast cancer is a heterogeneous disease, which is the most common malignancy in women. The incidence and mortality rates of breast cancer indicate that it is the leading cause of cancer-related deaths. The goal of the present review is to introduce biogenesis, function characteristics and types of circRNAs, and also their biological functions on breast cancer, especially as miRNA sponges. Additionally, we discuss their use as a new therapeutic target for the treatment of breast cancer.
dc.identifier.doi10.1007/s12282-020-01140-w
dc.identifier.endpage1057
dc.identifier.issn1340-6868
dc.identifier.issn1880-4233
dc.identifier.issue6
dc.identifier.pmid32715419
dc.identifier.scopus2-s2.0-85088644510
dc.identifier.scopusqualityQ1
dc.identifier.startpage1048
dc.identifier.urihttps://doi.org/10.1007/s12282-020-01140-w
dc.identifier.urihttps://hdl.handle.net/20.500.12418/30182
dc.identifier.volume27
dc.identifier.wosWOS:000552584900002
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer Japan Kk
dc.relation.ispartofBreast Cancer
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBreast cancer
dc.subjectcircRNAs
dc.subjectNoncoding RNA
dc.subjectmiRNA sponge
dc.titleCircular RNAs serve as miRNA sponges in breast cancer
dc.typeReview Article

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