C-type natriuretic peptide is associated with the severity of Crimean-Congo hemorrhagic fever

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dc.authoridYILMAZ, MEHMET BIRHAN -- 0000-0002-8169-8628; YILMAZ, Mehmet Birhan -- 0000-0002-8169-8628; Turgut, Okan -- 0000-0002-6847-3029; kukul guven, fatma mutlu -- 0000-0003-3755-6021en_US
dc.contributor.authorTurkdogan, Kenan Ahmet
dc.contributor.authorZorlu, Ali
dc.contributor.authorEngin, Aynur
dc.contributor.authorGuven, Fatma Mutlu Kukul
dc.contributor.authorPolat, Muhammed Mirhan
dc.contributor.authorTurgut, Okan Onur
dc.contributor.authorYilmaz, Mehmet Birhan
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T10:03:30Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T10:03:30Z
dc.date.issued2012
dc.department[Zorlu, Ali] Bulanik State Hosp, Dept Cardiol, Mus, Turkey -- [Turkdogan, Kenan Ahmet -- Guven, Fatma Mutlu Kukul] Isparta State Hosp, Dept Emergency, Isparta, Turkey -- [Engin, Aynur] Cumhuriyet Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Sivas, Turkey -- [Turgut, Okan Onur -- Yilmaz, Mehmet Birhan] Cumhuriyet Univ, Sch Med, Dept Cardiol, Sivas, Turkeyen_US
dc.description.abstractBackground: Crimean-Congo hemorrhagic fever (CCHF) is characterized by vascular dysfunction, indicating the involvement of endothelial cells. C-type natriuretic peptide (CNP) plays a critical role in the coordination of vascular tone and is associated with the prognosis in critically ill patients such as those with sepsis and septic shock. We investigated whether CNP is related to the severity of CCHF. Methods: Forty-eight consecutive patients with a laboratory confirmed diagnosis of CCHF and 40 age-sex-matched healthy volunteers as the control group were prospectively enrolled into the study. CCHF patients were classified according to the disease severity into a non-severe group (n = 28) and a severe group (n = 20). Results: The CNP levels were detected to be 0.43 (0.4-0.7) ng/ml in the control group, 0.87 (0.7-1.0) ng/ml in the non-severe CCFH group, and 1.27 (0.8-1.7) ng/ml in the severe CCHF group. According to the receiver operating characteristics curve analysis, the optimal cut-off value of CNP to predict disease severity was >1.22 ng/ml, with 89.3% specificity and 55% sensitivity. CNP >1.22 ng/ml, lactate dehydrogenase >480 IU/l, and aspartate aminotransferase >202 IU/l were found to have prognostic significance in the univariate analysis. In the multivariate logistic regression analysis by forward stepwise method, CNP >1.22 ng/ml (odds ratio 8.336, p = 0.016) and lactate dehydrogenase > 480 IU/l (odds ratio 16.206, p = 0.002) remained associated with disease severity after adjustment for confounding variables. Conclusions: CNP measurement could help in the risk stratification of patients with CCHF. (C) 2012 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.ijid.2012.04.009en_US
dc.identifier.endpageE620en_US
dc.identifier.issn1201-9712
dc.identifier.issue8en_US
dc.identifier.pmid22695238en_US
dc.identifier.scopus2-s2.0-84864395552en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpageE616en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.ijid.2012.04.009
dc.identifier.urihttps://hdl.handle.net/20.500.12418/9058
dc.identifier.volume16en_US
dc.identifier.wosWOS:000307124100007en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherELSEVIER SCI LTDen_US
dc.relation.ispartofINTERNATIONAL JOURNAL OF INFECTIOUS DISEASESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCrimean-Congo hemorrhagic feveren_US
dc.subjectC-type natriuretic peptideen_US
dc.subjectRisk stratificationen_US
dc.titleC-type natriuretic peptide is associated with the severity of Crimean-Congo hemorrhagic feveren_US
dc.typeArticleen_US

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