Quinoline-fused both non-peripheral and peripheral ZnII and MgII phthalocyanines: Anti-cholinesterase, anti- ?-glucosidase, DNA nuclease, antioxidant activities, and in silico studies

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dc.authoridhttps://orcid.org/0000-0002-0420-2043tr
dc.contributor.authorYalazan, Halise
dc.contributor.authorTüzün,Burak
dc.contributor.authorAkkaya, Didem
dc.contributor.authorBarut, Burak
dc.contributor.authorKantekin, Halit
dc.contributor.authorYıldırmıs, Sermet
dc.date.accessioned2023-04-12T05:31:45Z
dc.date.available2023-04-12T05:31:45Z
dc.date.issued08.04.2022tr
dc.departmentSivas Meslek Yüksekokulutr
dc.description.abstractQuinoline-fused ZnII (ZnPcp/ZnPcnp) and MgII (MgPcp/MgPcnp) phthalocyanines with four 4-methylquinolin-2-ol (1) at non-peripheral or peripheral positions of the phthalocyanine core have been synthesized via cyclotetramerization of phthalonitrile derivatives (CNp/CNnp) in the presence of zinc (II) and magnesium (II) metal ions in this study. After synthesis and characterization processes, anti-cholinesterase, anti-α-glucosidase, DNA nuclease, antioxidant activities, and in silico calculations of both peripheral and non-peripheral ZnII and MgII phthalocyanines were investigated. The inhibitory effects of metallated phthalocyanines on acetylcholinesterase, butyrylcholinesterase, and α-glucosidase enzymes were tested by spectrophotometric method. Theoretical methods are used to compare both the chemical and biological activities of the studied phthalonitrile derivatives and metallated phthalocyanine compounds.tr
dc.identifier.citationHalise Yalazan1 | Burak Tüzün2 | Didem Akkaya3 | Burak Barut3 | Halit Kantekin1 | Sermet Yıldırmıs¸3 1Faculty of Sciences, Department of Chemistry, Karadeniz Technical University, Trabzon, Turkey 2Plant and Animal Production Department, Technical Sciences Vocational School of Sivas, Sivas Cumhuriyet University, Sivas, Turkey 3Faculty of Pharmacy, Department of Biochemistry, Karadeniz Technical University, Trabzon, Turkeytr
dc.identifier.doi10.1002/aoc.6696en_US
dc.identifier.scopus2-s2.0-85129721444en_US
dc.identifier.scopusqualityN/A
dc.identifier.startpagee6696tr
dc.identifier.urihttps://hdl.handle.net/20.500.12418/13575
dc.identifier.volume2022tr
dc.identifier.wosWOS:000792942700001en_US
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofAppl Organomet Chem.en_US
dc.relation.publicationcategoryRaportr
dc.rightsinfo:eu-repo/semantics/openAccesstr
dc.subjectanti-cholinesterasetr
dc.subjectanti-α-glucosidasetr
dc.subjectmolecular dockingtr
dc.subjectphthalocyaninetr
dc.subjectPLIPtr
dc.titleQuinoline-fused both non-peripheral and peripheral ZnII and MgII phthalocyanines: Anti-cholinesterase, anti- ?-glucosidase, DNA nuclease, antioxidant activities, and in silico studiesen_US
dc.typeArticleen_US

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