Investigating the Potential of Lipids for Use as Biomarkers for Glioblastoma via an Untargeted Lipidomics Approach

Basit Öğe Kaydı
dc.authoridSoylemez, Burcak/0000-0001-8626-6915
dc.authoridSahin-Bolukbasi, Serap/0000-0003-1057-2558
dc.contributor.authorSoylemez, Burcak
dc.contributor.authorBulut, Zekeriya
dc.contributor.authorBolukbas, Serap Sahin
dc.date.accessioned2024-10-26T18:05:21Z
dc.date.available2024-10-26T18:05:21Z
dc.date.issued2023
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractObjective : The types and functions of lipids involved in glioblastoma (GB) are not well known. Lipidomics is a new field that examines cellular lipids on a large scale and novel aplication of lipidomics in the biomedical sciences have emerged. This study aimed to investigate the potential of blood lipids for use as biomarkers for the diagnosis of GB via untargated lipidomic approach. Gaining a deeper understanding of lipid metabolism in patients with GB can contribute to the early diagnosis with GB patiens and also development of novel and better therapeutic options.Methods : This study was performed using blood samples collected from 14 patients (eight females and six males) and 14 controls (eight females and six males). Lipids were extracted from blood samples and quantified using phosphorus assay. Lipid profiles of between patients with GB and controls were compared via an untargeted lipidomics approach using 6530 Accurate-Mass Q-TOF LC/MS mass spectrometer.Results : According to the results obtained using the untargeted lipidomics approach, differentially regulated lipid species, including fatty acid (FA), glycerolipid (GL), glycerophospholipid (PG), saccharolipid (SL), sphingolipid (SP), and sterol lipid (ST) were identified between in patients with GB and controls.Conclusion : Differentially regulated lipids were identified in patients with GB, and these lipid species were predicted as potential biomarkers for diagnosis of GB.
dc.identifier.doi10.3340/jkns.2022.0091
dc.identifier.issn2005-3711
dc.identifier.issn1598-7876
dc.identifier.issue2
dc.identifier.pmid36530132
dc.identifier.scopus2-s2.0-85150728253
dc.identifier.scopusqualityN/A
dc.identifier.urihttps://doi.org/10.3340/jkns.2022.0091
dc.identifier.urihttps://hdl.handle.net/20.500.12418/28962
dc.identifier.volume66
dc.identifier.wosWOS:001047862500001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherKorean Neurosurgical Soc
dc.relation.ispartofJournal of Korean Neurosurgical Society
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectGlioblastoma
dc.subjectLipidomics
dc.subjectElectrospray Ionization mass spectrometry
dc.subjectBiomarkers
dc.subjectCancer
dc.titleInvestigating the Potential of Lipids for Use as Biomarkers for Glioblastoma via an Untargeted Lipidomics Approach
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksyonu
Scopus İndeksli Yayınlar Koleksiyonu