In Vitro Evaluation of Antioxidant, Anti-Inflammatory, Antimicrobial and Wound Healing Potential of Thymus Sipyleus Boiss. Subsp. Rosulans (Borbas) Jalas

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dc.authoridDIREN SIGIRCI, BELGI/0000-0001-7153-7428
dc.authoridUSTUN ALKAN, Fulya/0000-0003-1782-9467
dc.authoridAkpulat, Huseyin Askin/0000-0001-8394-2746
dc.authoridANLAS, CEREN/0000-0002-7997-016X
dc.authoridAK, SEYYAL/0000-0002-6687-8401
dc.authoridkoca, ufuk/0000-0002-5216-7588
dc.authoridustuner, oya/0000-0002-4354-8207
dc.contributor.authorUstuner, Oya
dc.contributor.authorAnlas, Ceren
dc.contributor.authorBakirel, Tulay
dc.contributor.authorUstun-Alkan, Fulya
dc.contributor.authorSigirci, Belgi Diren
dc.contributor.authorAk, Seyyal
dc.contributor.authorAkpulat, Huseyin Askin
dc.date.accessioned2024-10-26T18:09:05Z
dc.date.available2024-10-26T18:09:05Z
dc.date.issued2019
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractThymus sipyleus Boiss. subsp. rosulans (Borbas) Jalas (TS) is a commonly used plant in the treatment of various complaints, including skin wounds in Turkish folk medicine. Despite the widespread traditional use of TS, there is not any scientific report confirming the effectiveness of this plant on the healing process. This research aimed to investigate the effects of different extracts obtained from TS on biological events during wound healing, on a cellular basis. In this context, proliferative activities of the extracts, as well as the effects on wound closure and hydroxyproline synthesis, were determined. In addition to wound healing properties, the antioxidant, antibacterial and anti-inflammatory activities of the extracts were evaluated. Decoction (D) and infusion (I) extracts contained the highest amount of phenolic content and showed the most potent activity against DPPH radical. All extracts exhibited complete protection against the damage induced by hydrogen peroxide (H2O2) by increasing cell viability compared to only H2O2-treated groups, both in co-treatment and pre-treatment protocols. None of the extracts exhibited cytotoxic activity, and most of the extracts from the TS stimulated fibroblast proliferation and migration. All TS extracts exert anti-inflammatory activity by suppressing the overproduction of tumor necrosis factor-alpha (TNF-alpha) and nitric oxide (NO). The most pronounced activity on hydroxyproline synthesis was observed in D extract. In summary, it was observed that TS extracts can promote the healing process by enhancing fibroblast migration, proliferation and collagen synthesis as well as suppressing pro-inflammatory cytokines. The obtained data in this work support the traditional use of TS as a valuable plant-based compound for the treatment of wounds.
dc.description.sponsorshipResearch Fund of Istanbul University [22886]
dc.description.sponsorshipThis research was funded by the Research Fund of Istanbul University (Project no: 22886).
dc.identifier.doi10.3390/molecules24183353
dc.identifier.issn1420-3049
dc.identifier.issue18
dc.identifier.pmid31540139
dc.identifier.scopus2-s2.0-85072539637
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/molecules24183353
dc.identifier.urihttps://hdl.handle.net/20.500.12418/29948
dc.identifier.volume24
dc.identifier.wosWOS:000488830500145
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofMolecules
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectThymus sipyleus Boiss
dc.subjectsubsp
dc.subjectrosulans (Borbas) Jalas
dc.subjectwound healing
dc.subjectantioxidant
dc.subjectanti-inflammatory
dc.subjectantibacterial
dc.titleIn Vitro Evaluation of Antioxidant, Anti-Inflammatory, Antimicrobial and Wound Healing Potential of Thymus Sipyleus Boiss. Subsp. Rosulans (Borbas) Jalas
dc.typeArticle

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