Investigation of NEAT1, IFNG-AS1, and NRIR expression in Crimean-Congo hemorrhagic fever

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dc.authoridBayyurt, Burcu/0000-0002-5618-457X
dc.contributor.authorBayyurt, Burcu
dc.contributor.authorBakir, Mehmet
dc.contributor.authorEngin, Aynur
dc.contributor.authorOksuz, Caner
dc.contributor.authorArslan, Serdal
dc.date.accessioned2024-10-26T18:03:55Z
dc.date.available2024-10-26T18:03:55Z
dc.date.issued2021
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractCrimean-Congo hemorrhagic fever (CCHF), whose causative agent is CCHF orthonairovirus (CCHFV), demonstrates different symptoms in patients. Long noncoding RNAs (lncRNAs) take part in various pathological processes of viral diseases. They are prominent regulators of antiviral immune responses. To our knowledge, this study is the first study to investigate nuclear paraspeckle assembly transcript 1 (NEAT1), interferon (IFN) gamma antisense RNA 1 (IFNG-AS1), and negative regulator of IFN response (NRIR) expression in CCHF in the literature. We selected these lncRNAs because they are related to IFN signal or IFN-stimulated genes. We investigated NEAT1, IFNG-AS1, and NRIR gene expression in patients with CCHF. Total RNA was extracted from blood samples of 100 volunteers and NEAT1, IFNG-AS1, and NRIR expression were measured using a quantitative real-time polymerase chain reaction. NRIR expression was statistically significant in cases versus controls (p < .001), fatals versus controls (p < .001), and fatals versus nonfatals (p = .01). Furthermore, NRIR was found statistically significant at some clinical parameters including alanine aminotransferase (p = .03), international normalized ratio (p = .03), prothrombin time (p = .02), and active partial thromboplastin time (p = .01) in CCHF cases. NEAT1 and IFNG-AS1 expression were downregulated in the case and fatal groups which were compared with controls. Our results demonstrate that NRIR may be important in CCHF pathogenesis and the target of CCHF treatment.
dc.description.sponsorshipTUBITAK [117S146]; Scientific Research Council of Sivas Cumhuriyet University [T-771]
dc.description.sponsorshipTUBITAK, Grant/Award Number: 117S146; Scientific Research Council of Sivas Cumhuriyet University, Grant/Award Number: T-771
dc.identifier.doi10.1002/jmv.26606
dc.identifier.endpage3304
dc.identifier.issn0146-6615
dc.identifier.issn1096-9071
dc.identifier.issue6
dc.identifier.pmid33064349
dc.identifier.scopus2-s2.0-85094664783
dc.identifier.scopusqualityQ1
dc.identifier.startpage3300
dc.identifier.urihttps://doi.org/10.1002/jmv.26606
dc.identifier.urihttps://hdl.handle.net/20.500.12418/28658
dc.identifier.volume93
dc.identifier.wosWOS:000583186900001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Medical Virology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCrimean– Congo hemorrhagic fever
dc.subjectgene expression
dc.subjectlong noncoding RNA
dc.titleInvestigation of NEAT1, IFNG-AS1, and NRIR expression in Crimean-Congo hemorrhagic fever
dc.typeArticle

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