Antioxidant, antimicrobial, and anticancer effects of Achillea filipendulina L. against colon cancer

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dc.authoridTUNC, Tutku/0000-0002-8274-9386
dc.contributor.authorTunc, Tutku
dc.contributor.authorAkin, Seyda
dc.contributor.authorAykac, Okan
dc.contributor.authorHepokur, Ceylan
dc.contributor.authorDuran, Serap
dc.contributor.authorOzpinar, Hulya
dc.date.accessioned2025-05-04T16:45:37Z
dc.date.available2025-05-04T16:45:37Z
dc.date.issued2024
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractObjective: To investigate the antioxidant, antimicrobial, and anticancer effects of Achillea filipendulina. Methods: Phytochemical content was analyzed by GC-MS. Antioxidant activity was assayed by DPPH, total antioxidant status, total oxidant status, and iron reduction tests. Antimicrobial activity was assessed using the MIC assay. Anticancer activity was detected via MTT assay, followed by analysis of the apoptotic process using annexin V and caspase 3/7. miR-519d and Dvl-1 expression were assessed by RT-PCR, and molecular docking analysis was also performed. Results: The ethanol extract of Achillea filipendulina showed the strongest anticancer effect. A significant increase in miR-519d expression was observed in HT29 cells, while a decrease in Dvl-1 expression was noted. DPPH, FRAP, total antioxidant status, and total oxidant assays showed high antioxidant activity. The hexane and ethanol extracts were effective against Streptococcus mutans (MIC<50 g/mL), while the ethanol extract was effective against Enterococcus faecalis and Candida albicans (MIC<50 g/mL). Molecular docking studies also confirmed that ethanol extracts could act on the Wnt pathway. GC-MS analysis showed high level of eucalyptol and borneol content in the extract. Conclusions: Ethanol extract of Achillea filipendulina has anticancer effect and can be used in colon cancer treatments.
dc.description.sponsorshipUniversity Students Research Projects Program [TUBITAK-2209-A]
dc.description.sponsorshipWe gratefully acknowledge the support of TUBITAK-2209-A University Students Research Projects Program for the antioxidant activity assay of this research.
dc.identifier.doi10.4103/apjtb.apjtb_515_24
dc.identifier.issn2221-1691
dc.identifier.issn2588-9222
dc.identifier.issue12
dc.identifier.scopus2-s2.0-85213511740
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.4103/apjtb.apjtb_515_24
dc.identifier.urihttps://hdl.handle.net/20.500.12418/35155
dc.identifier.volume14
dc.identifier.wosWOS:001384847000004
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWolters Kluwer Medknow Publications
dc.relation.ispartofAsian Pacific Journal of Tropical Biomedicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250504
dc.subjectAchillea filipendulina
dc.subjectWnt signaling pathway
dc.subjectmiRNA-519d
dc.subjectDvl-1
dc.subjectColon cancer
dc.subjectAntioxidant
dc.subjectAntimicrobial
dc.titleAntioxidant, antimicrobial, and anticancer effects of Achillea filipendulina L. against colon cancer
dc.typeArticle

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