A Simple and Efficient Procedure Toward 2-Thioxoquinazolin-4(1H)-One Derivatives

Basit Öğe Kaydı
dc.contributor.authorShourkaei, Fateme Ahmadi
dc.contributor.authorRanjbar, Parviz Rashidi
dc.contributor.authorMahdavi, Mohammad
dc.contributor.authorTuzun, Burak
dc.contributor.authorTaslimi, Parham
dc.date.accessioned2024-10-26T18:09:26Z
dc.date.available2024-10-26T18:09:26Z
dc.date.issued2024
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractA facile synthetic route for constructing 2-thioxoquinazolin-4(1H)-one derivative through cyclization reactions using readily available starting materials 2-aminobenzoic acids, alkyl/aryl amines, and carbon disulfide is described. These reactions occur under mild conditions, producing the desired products with good to high yields. Molecular docking was conducted to assess the activities of the 2-thioxoquinazolin-4(1H)-one derivative against breast cancer protein (PDB ID: 1JNX), liver cancer protein (PDB ID: 2H80), and colon cancer protein (PDB ID: 4UYA). Furthermore, an ADME/T analysis was performed to evaluate the impact of these compounds on human metabolism.
dc.description.sponsorshipScientific Research Project Fund of Sivas Cumhuriyet University (CUBAP) [RGD-020]
dc.description.sponsorshipThe High Performance and Grid Computing Center at TUBITAK ULAKBIM performed the majority of the numerical calculations used in this study (TRUBA resources). Under project number RGD-020, the Scientific Research Project Fund of Sivas Cumhuriyet University (CUBAP) provided funding for this work.
dc.identifier.endpage1114
dc.identifier.issn1021-9986
dc.identifier.issue3
dc.identifier.scopus2-s2.0-85201274624
dc.identifier.scopusqualityQ3
dc.identifier.startpage1103
dc.identifier.urihttps://hdl.handle.net/20.500.12418/30098
dc.identifier.volume43
dc.identifier.wosWOS:001315948900001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherJihad Daneshgahi
dc.relation.ispartofIranian Journal of Chemistry & Chemical Engineering-International English Edition
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subject2-Thioxoquinazolin-4(1H)-one Derivative
dc.subjectCyclization reaction
dc.subjectMolecular docking
dc.subjectBreast cancer
dc.subjectLiver cancer
dc.subjectADME/T
dc.titleA Simple and Efficient Procedure Toward 2-Thioxoquinazolin-4(1H)-One Derivatives
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu