Oxidative stress markers in laparoscopic vs. open appendectomy for acute appendicitis: A double-blind randomized study

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dc.contributor.authorAktimur, Recep
dc.contributor.authorGokakin, Ali Kagan
dc.contributor.authorDeveci, Koksal
dc.contributor.authorAtabey, Mustafa
dc.contributor.authorTopcu, Omer
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:45:45Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:45:45Z
dc.date.issued2016
dc.department[Aktimur, Recep] Samsun Training & Res Hosp, Dept Gen Surg, TR-55200 Ilkadim, Samsun, Turkey -- [Gokakin, Ali Kagan -- Atabey, Mustafa -- Topcu, Omer] Cumhuriyet Univ, Sch Med, Dept Gen Surg, Sivas, Turkey -- [Deveci, Koksal] Cumhuriyet Univ, Sch Med, Dept Biochem, Sivas, Turkeyen_US
dc.description.abstractBackground: Oxidative stress is a complicated process, which was defined as an increase in prooxidants and decrease in antioxidants caused by various mechanisms, including inflammation and surgical trauma. The association between acute appendicitis and oxidative stress has been showed in previous studies. However, comparison of oxidative stress in laparoscopic or open appendectomy (OA) has not been established. Patients and Methods: Patients who were diagnosed as acute appendicitis between October 2012 and January 2013 were randomized to open (OA, n = 50) and laparoscopic appendectomy (LA, n = 50). Blood samples for oxidative stress markers (total oxidant status [TOS] and total antioxidant status [TAS]), C-reactive protein (CRP) and white blood cells (WBC's) were collected just before the surgery and 24 h after surgery. Results: There were no differences in preoperative values of WBC and CRP between LA and OA groups (P = 0.523 and 0.424), however, in postoperative 24(th) h, CRP was reduced in LA group (P = 0.031). There were no differences in preoperative levels of TOS, TAS, and oxidative stress index (OSI) between LA and OA groups. In the postoperative 24(th) h, TOS and OSI were found to be significantly higher in OA group when compared to LA group (P = 0.017 and 0.002) whereas no difference was detected in TAS level in the postoperative 24(th) h (P = 0.172). Conclusions: This double-blind, randomized clinical trial provides evidence that LA for uncomplicated appendicitis is associated with significantly lower oxidative stress compared with OA. Some of the advantages of LA may be attributed to the significant reduction of oxidative stress in these patients.en_US
dc.identifier.doi10.4103/0972-9941.156203en_US
dc.identifier.endpage147en_US
dc.identifier.issn0972-9941
dc.identifier.issn1998-3921
dc.identifier.issue2en_US
dc.identifier.pmid27073307en_US
dc.identifier.scopus2-s2.0-84962423483en_US
dc.identifier.scopusqualityQ3
dc.identifier.startpage143en_US
dc.identifier.urihttps://dx.doi.org/10.4103/0972-9941.156203
dc.identifier.urihttps://hdl.handle.net/20.500.12418/7396
dc.identifier.volume12en_US
dc.identifier.wosWOS:000372998900010en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMEDKNOW PUBLICATIONS & MEDIA PVT LTDen_US
dc.relation.ispartofJOURNAL OF MINIMAL ACCESS SURGERYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcute appendicitisen_US
dc.subjectlaparoscopic appendectomyen_US
dc.subjectoxidative stressen_US
dc.titleOxidative stress markers in laparoscopic vs. open appendectomy for acute appendicitis: A double-blind randomized studyen_US
dc.typeArticleen_US

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