The combination of metformin and high glucose increased longevity of Caenorhabditis elegans a DAF-16/FOXO-independent manner: cancer/diabetic model via C. elegans

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dc.authoridCetin, Ali/0000-0002-5767-7894
dc.contributor.authorBerk, Seyda
dc.contributor.authorCetin, Ali
dc.contributor.authorOzdemir, Ozgur Ulkue
dc.contributor.authorPektas, Ayse Nur
dc.contributor.authorYurtcu, Nazan
dc.contributor.authorDastan, Sevgi Durna
dc.date.accessioned2025-05-04T16:45:49Z
dc.date.available2025-05-04T16:45:49Z
dc.date.issued2024
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractIntroduction Sedentary lifestyles and diets with high glycemic indexes are considered to be contributing factors to the development of obesity, type 2 diabetes in humans. Metformin, a biguanide medication commonly used to treat type 2 diabetes, has been observed to be associated with longevity; however, the molecular mechanisms underlying this observation are still unknown.Methods The effects of metformin and high glucose, which have important roles in aging-related disease such as diabetes and cancer, were studied in lin-35 worms because they are associated with cancer-associated pRb function in mammals and have a tumour suppressor property.Results and Discussion According to our results, the negative effect of high glucose on egg production of lin-35 worms was greater than that of N2 worms. High glucose shortened lifespan and increased body length and width in individuals of both strains. Metformin treatment alone extended the lifespan of N2 and lin-35 worms by reducing fertilization efficiency. However, when metformin was administered in the presence of high glucose, the lifespan of lin-35 worms was clearly longer compared to N2 worms. Additionally, we conclude that glucose and metformin in lin35 worms can extend life expectancy through a DAF-16/FOXO-independent mechanism. Furthermore, the results of this study will provide a new perspective on extending mammalian lifespan through the model organism C. elegans.
dc.description.sponsorshipSivas Cumhuriyet University Scientific Research Projects (CUBAP) [F-2021-636]
dc.description.sponsorshipThe authors are thankful for the ongoing support of the Advanced Technology and Research Center (CUTAM), Sivas Cumhuriyet University. Further, we would like to thank Nevra Nur Emlik and Gizem Demirkoparan, senior students of the Department of Molecular Biology and Genetics at Sivas Cumhuriyet University, for providing the necessary convenience and encouragement for the maintain of the C. elegans culture.
dc.identifier.doi10.3389/fendo.2024.1435098
dc.identifier.issn1664-2392
dc.identifier.pmid39558974
dc.identifier.scopus2-s2.0-85209552381
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.3389/fendo.2024.1435098
dc.identifier.urihttps://hdl.handle.net/20.500.12418/35223
dc.identifier.volume15
dc.identifier.wosWOS:001356348800001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherFrontiers Media Sa
dc.relation.ispartofFrontiers in Endocrinology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250504
dc.subjectaging
dc.subjectC. elegans
dc.subjectglucose
dc.subjectlifespan
dc.subjectlin-35
dc.subjectmetformin
dc.titleThe combination of metformin and high glucose increased longevity of Caenorhabditis elegans a DAF-16/FOXO-independent manner: cancer/diabetic model via C. elegans
dc.typeArticle

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