The Determination of In vitro Antioxidant and Cytotoxic Activities of Resin Obtained from Cilician Fir (Abies cilicica (Antoine & Kotschy) Carriere)

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dc.authoridAkpulat, Huseyin Askin/0000-0001-8394-2746
dc.authoridSahin-Bolukbasi, Serap/0000-0003-1057-2558
dc.authoridUcar, Esra/0000-0001-6327-4779
dc.contributor.authorUcar, Esra
dc.contributor.authorSahin-Bolukbasi, Serap
dc.contributor.authorUlu, Mustafa
dc.contributor.authorAskin Akpulat, Huseyin
dc.date.accessioned2024-10-26T18:00:18Z
dc.date.available2024-10-26T18:00:18Z
dc.date.issued2020
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractIn this study, the antioxidant and cytotoxic activities of resin obtained from the Cilician Fir plant were evaluated. This resin has antioxidant activity according to 2,2'-Azino-bis-(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) radical scavenging assay. The in vitro cytotoxic activity of the resin was investigated against a panel of human cancer cells (MDA-MB-231, Hep G2, PC-3, U-87, MCF-7, HT-29) with the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay for 48 h. Normal human lung fibroblast cells (WI-38) were used as healthy cells. The results indicated that the in vitro cytotoxic activity of the resin depends on the cell line type and concentration of the resin. According to the IC50 values, the resin has the most cytotoxic activity on endometrial adenocarcinoma cancer cells (IC50=8.94 +/- 0.03 mu g mL(-1)) compared to other cancer cells. The results also indicated that Ishikawa endometrial adenocarcinoma cells, which have Selectivity Index (SI) value >2, have the most sensitivity against the resin. This study provides the first evidence that the resin inhibits the different cancer cells' growth.
dc.identifier.doi10.18016/ksutarimdoga.vi.720675
dc.identifier.endpage1509
dc.identifier.issn2619-9149
dc.identifier.issue6
dc.identifier.startpage1503
dc.identifier.trdizinid432408
dc.identifier.urihttps://doi.org/10.18016/ksutarimdoga.vi.720675
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/432408
dc.identifier.urihttps://hdl.handle.net/20.500.12418/27621
dc.identifier.volume23
dc.identifier.wosWOS:000592231400013
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherKahramanmaras Sutcu Imam Univ Rektorlugu
dc.relation.ispartofKsu Tarim ve Doga Dergisi-Ksu Journal of Agriculture and Nature
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAbies
dc.subjectAntioxidant
dc.subjectAnticancer
dc.subjectCilician Fir
dc.subjectCytotoxicity
dc.titleThe Determination of In vitro Antioxidant and Cytotoxic Activities of Resin Obtained from Cilician Fir (Abies cilicica (Antoine & Kotschy) Carriere)
dc.typeArticle

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