Hypoxia and Normoxia Preconditioned Olfactory Stem Cells Against Noise-Induced Hearing Loss

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dc.contributor.authorDurna, Yusuf M.
dc.contributor.authorYigit, Ozgur
dc.contributor.authorEdizer, Deniz T.
dc.contributor.authorDastan, Sevgi Durna
dc.contributor.authorGul, Mehmet
dc.contributor.authorOvali, Ercument
dc.date.accessioned2025-05-04T16:46:53Z
dc.date.available2025-05-04T16:46:53Z
dc.date.issued2024
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractObjective:Noise-induced hearing loss is one of the leading causes of permanent hearing loss in the adult population. In this experimental study, the authors aimed to investigate the effectiveness of hypoxia and normoxia preconditioned olfactory stem cells against noise trauma.Methods:Twenty-seven female guinea pigs were enrolled. Two guinea pigs were sacrificed for harvesting olfactory tissue and 1 for examining the architecture of the normal cochlea. The remaining 24 guinea pigs were exposed to noise trauma for 1 day and then randomly divided into 3 groups: intracochlear injection of (i) normoxic olfactory stem cells, (ii) hypoxic olfactory stem cells, and (iii) physiological serum. Auditory brainstem response (ABR) measurement was performed before and 2 weeks after noise trauma and weekly for 3 weeks following intracochlear injection. Both click and 16 kHz tone-burst stimuli were used for detection of ABR.Results:No significant difference was noted between the groups before and 2 weeks after noise trauma. ABR thresholds detected after intracochlear injections were significantly higher in the control group compared with stem cell groups. However, no significant difference was detected between the stem cell groups. Fluourescence microscopy revealed better engraftment for hypoxic stem cells. Light and electron microscopy examinations were consistent with predominant degenerative findings in the control group, whereas normoxic group had more similar findings with normal cochlea compared with hypoxic group.Conclusion:Olfactory stem cells were demonstrated to have the potential to have beneficial effects on noise trauma.
dc.identifier.doi10.1097/SCS.0000000000010660
dc.identifier.endpagee812
dc.identifier.issn1049-2275
dc.identifier.issn1536-3732
dc.identifier.issue8
dc.identifier.pmid39356227
dc.identifier.scopus2-s2.0-85206692743
dc.identifier.scopusqualityQ3
dc.identifier.startpagee807
dc.identifier.urihttps://doi.org/10.1097/SCS.0000000000010660
dc.identifier.urihttps://hdl.handle.net/20.500.12418/35382
dc.identifier.volume35
dc.identifier.wosWOS:001354718800073
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofJournal of Craniofacial Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250504
dc.subjectEngraftment
dc.subjecthypoxia
dc.subjectnoise-induced hearing loss
dc.subjectnormoxia
dc.subjectolfactory stem cell
dc.titleHypoxia and Normoxia Preconditioned Olfactory Stem Cells Against Noise-Induced Hearing Loss
dc.typeArticle

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