Expression levels of some genes in the MAPK pathway (DUSP1, DUSP2, DUSP4, DUSP6 and DUSP10) in eyelid tumor tissue

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dc.authoridSilig, Yavuz/0000-0002-0562-7457
dc.authoridTAS, Ayca/0000-0002-7132-1325
dc.authoridErdogan, Haydar/0000-0002-9337-6968
dc.contributor.authorOzmen, Esma
dc.contributor.authorTas, Ayca
dc.contributor.authorAkin, Dilara Fatma
dc.contributor.authorErdogan, Haydar
dc.contributor.authorSilig, Yavuz
dc.date.accessioned2025-05-04T16:45:56Z
dc.date.available2025-05-04T16:45:56Z
dc.date.issued2024
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractObjectives To control mitogen-activated protein kinases (MAPK) signaling pathways involved in the onset and progression of cancer, dual specificity phosphatases (DUSPs/MKP) are essential. This study seeks to detect the correlation between eyelid tumors and the genes DUSPs, known for their influence on MAPK signaling pathways. Additionally, we aim to juxtapose our findings with analyses from various bioinformatics databases.Methods Expression levels of relevant genes in cDNA samples were determined by quantitative PCR method. Open-access databases were used for mutation analysis of relevant genes, mRNA expression changes, and survival analyses, and the STRING database was used for protein-protein interactions.Results It was found that the expression of DUSP1 and DUSP2 showed a significant decrease in the tumor tissue, while a significant increase was detected in the DUSP4 and DUSP6 genes. Additionally, when we compared the study genes with the Cancer Genome Atlas program cancer cohorts, it was found that the DUSP1 and DUSP10 gene expression profiles were downregulated in uveal melanoma compared to other cancer cohorts.Conclusions Significant and obvious changes were observed in the DUSP genes we studied in eyelid tumors. However, the relationship between these genes and cancer must be studied more. Considering that these enzymes are effective in cell proliferation, differentiation, and apoptosis, it would be appropriate to plan comprehensive studies on their interactions with other proteins they interact with in the MAPK pathway.
dc.description.sponsorshipThis work is supported by the Scientific Research Project Fund of Sivas Cumhuriyet University (CUBAP) under Project number T-789.
dc.description.sponsorshipOur study used on data sourced from the publicly available TCGA Research Network database at https://www.cancer.gov/tcga. We express our gratitude to the TCGA and GEPIA databases for providing access to this valuable dataset.
dc.identifier.doi10.1515/tjb-2023-0279
dc.identifier.endpage764
dc.identifier.issn0250-4685
dc.identifier.issn1303-829X
dc.identifier.issue6
dc.identifier.scopus2-s2.0-85209661191
dc.identifier.scopusqualityQ3
dc.identifier.startpage757
dc.identifier.urihttps://doi.org/10.1515/tjb-2023-0279
dc.identifier.urihttps://hdl.handle.net/20.500.12418/35292
dc.identifier.volume49
dc.identifier.wosWOS:001352007200001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWalter De Gruyter Gmbh
dc.relation.ispartofTurkish Journal of Biochemistry-Turk Biyokimya Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250504
dc.subjecteyelid
dc.subjecttumor
dc.subjectDUSP
dc.subjectexpression
dc.subjectin silico analysis
dc.titleExpression levels of some genes in the MAPK pathway (DUSP1, DUSP2, DUSP4, DUSP6 and DUSP10) in eyelid tumor tissue
dc.typeArticle

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