Calcium phosphate nano powder biosynthesis from sea urchin shells: a response surface approach

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dc.contributor.authorOksuz, Kerim Emre
dc.contributor.authorSen, Iker
dc.contributor.authorErsan, Mehtap
dc.date.accessioned2025-05-04T16:47:25Z
dc.date.available2025-05-04T16:47:25Z
dc.date.issued2024
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractIn this experimental study, calcium phosphate Ca-3(PO4)(2) nanopowders, in the form of nano-hydroxyapatite (n-HA), were successfully synthesized from sea urchin shells (Diadema setosum, Leske, 1778) via a process involving precipitation and heat treatment method at various calcination temperatures (800 to 1200 degrees C). The optimal conditions for producing n-HA with maximum free CaO content were determined using response surface methodology (RSM) through a Box-Behnken Design. Key findings demonstrated that calcination temperature, calcination time, and ball-milling time significantly influenced the free CaO content. The study identified that a calcination temperature of 1100.73 degrees C for 2.78 h for CaO derived from sea urchin shells, combined with a ball-milling time of 66.37 h, resulted in the highest purity of n-HA. The biosynthesized n-HA exhibited desirable characteristics for bone and dental restoration applications, as confirmed by comprehensive analyses of functional group vibrations, chemical structure/composition, molecular interactions, surface morphology, and particle size distribution. These findings underscore the potential of using invasive sea urchin shells as a sustainable and effective source for n-HA production in biomedical applications.
dc.identifier.doi10.1007/s11051-024-06179-w
dc.identifier.issn1388-0764
dc.identifier.issn1572-896X
dc.identifier.issue11
dc.identifier.scopus2-s2.0-85209537528
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1007/s11051-024-06179-w
dc.identifier.urihttps://hdl.handle.net/20.500.12418/35606
dc.identifier.volume26
dc.identifier.wosWOS:001360161600002
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofJournal of Nanoparticle Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250504
dc.subjectBiomaterials
dc.subjectBiomedical use
dc.subjectCalcination
dc.subjectNano-hydroxyapatite
dc.subjectCa-3(PO4)(2) nano powders
dc.subjectCaO
dc.subjectResponse surface methodology
dc.titleCalcium phosphate nano powder biosynthesis from sea urchin shells: a response surface approach
dc.typeArticle

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